骨质疏松症骨折风险评估的生物力学研究进展  

ADVANCES OF BIOMECHANICAL RESEARCH IN ASSESSING THE RISK OF OSTEOPOROTIC FRACTURE

作　　者：刘盼[1] 白旭锋 黄国友 张作启 LIU Pan;BAI Xufeng;HUANG Guoyou;ZHANG Zuoqi(School of Mechanics and Safety Engineering,Zhengzhou University,Zhengzhou 450001,China;School of Civil Engineering,Wuhan University,Wuhan 430072,China)

机构地区：[1]郑州大学力学与安全工程学院,郑州450001 [2]武汉大学土木建筑工程学院,武汉430072

出　　处：《力学与实践》2025年第2期273-284,共12页Mechanics in Engineering

基　　金：国家自然科学基金(12102309,12272279);中央高校基本科研业务费专项资金项目(2042024kf0034)资助。

摘　　要：骨质疏松症导致骨折风险上升的根本原因在于骨质疏松症骨力学性能的劣化,核心是力学问题。本文将重点介绍生物力学在骨质疏松症骨折风险评估领域的研究进展,主要包括:(1)细胞生物力学在解析骨质疏松症生物学机理中的最新进展;(2)多尺度生物力学在不同层级上对骨骼力学性能的前沿探索;(3)人工智能结合生物力学分析在预测骨折风险中的应用。本综述旨在为骨质疏松症骨折风险评估与临床诊疗提供参考和指导。High risk of Osteoporosis(OP)bone fractures essentially stems from the OP induced considerable mechanical deterioration of bones,in which mechanics certainly plays a crucial role.This article reviewed the advancements in biomechanics field on the risk assessment of OP bone fractures,mainly covering the following three aspects:(1)the relevant developments of cell biomechanics on the biological mechanisms of OP;(2)the related research progress on the mechanical properties of bones across multiple scales;and(3)the relevant applications of artificial intelligence technology in the assessment of OP bone fracture risk.This work aims to provide scientific guidance for the assessment,prevention and control of OP bone fracture risk.

关 键 词：骨质疏松症 骨折风险 生物力学 骨力学性能 

分 类 号：R318.01[医药卫生—生物医学工程]