光敏剂应用于光动力治疗的研究进展  

Research progress on the application of photosensitizers in photodynamic therapy

作　　者：李潇 杨敏[1] 彭黔荣 LI Xiao;YANG Min;PENG Qianrong(College of Pharmacy,Guizhou University,Guiyang 550000,Guizhou,China;Technical Center of Guizhou Zhongyan Industry Co,Ltd,Guiyang 550009,Guizhou,China)

机构地区：[1]贵州大学药学院,贵州贵阳550000 [2]贵州中烟工业有限责任公司技术中心,贵州贵阳550009

出　　处：《化学研究》2025年第2期168-179,共12页Chemical Research

基　　金：国家自然科学基金(21562014);贵州中烟科技项目(黔烟工技[2015]8号:Z164004)。

摘　　要：光动力治疗(PDT)是一种新的非入侵性肿瘤治疗方法,通过与氧间接作用生成活性氧(ROS),以此来杀灭肿瘤,治疗过程包含三个主要因素:适宜波长的光、光敏剂、氧。光敏剂经过几十年的研究已发展到第三代光敏剂,第三代光敏剂解决了第一代、第二代光敏剂普遍存在的水溶性差的问题,并具有一定的肿瘤靶向能力。此综述简述了光动力治疗的原理,并着重介绍了光敏剂用于PDT的研究进展。Photodynamic therapy(PDT)is a new non-invasive tumor treatment method that generates reactive oxygen species(ROS)through indirect interaction with oxygen to kill tumors,in which process involves three main factors:light with appropriate wavelength,photosensitizers and oxygen.After decades of research,photosensitizers have developed into the third generation photosensitizers,which have solved the common problem of poor water solubility in the first and second generation photosensitizers and have certain tumor targeting abilities.This review briefly describes the principle of PDT and focuses on introducing the research progress of photosensitizers for PDT.

关 键 词：光动力治疗 活性氧 光敏剂 研究进展 

分 类 号：O69[理学—化学]