漫射相关光谱在脑血流自动调节中的研究  

Study of Diffuse Correlation Spectroscopy in Automatic Regulation of Cerebral Blood Flow

作　　者：徐舒宁 桂志国[1] 尚禹[1] XU Shuning;GUI Zhiguo;SHANG Yu(State Key Laboratory of Dynamic Testing Technology Jointly Established by Province and Ministry,North University of China,Taiyuan Shanxi 030051,China)

机构地区：[1]中北大学省部共建动态测试技术国家重点实验室,山西太原030051

出　　处：《中国医疗设备》2025年第4期44-49,共6页China Medical Devices

基　　金：国家重点研发计划(2023YFE0202800);山西省基础研究计划项目(202203021221097,202203021211100);中北大学研究生科技立项(20231932);山西省研究生教育创新项目(2022Y621)。

摘　　要：目的探究脑部血流微循环、血压与脑自动调节之间的相互作用。方法招募20例健康成年受试者,分别完成4组实验任务:直立倾斜任务、大腿袖带加压任务、主动站立任务和蹲立任务,以引发脑部毛细血流和血压的同步变化。采用漫射相关光谱测量脑血流,利用指尖描记血压技术实时记录血压,并通过取整算法匹配两者数据频率,以确保数据处理一致性。此外,设定反应时间、反应变化率、积分等指标,定量评估血流与血压的动态变化。结果主动站立任务中,血压与血流呈现显著强正相关(r=0.65,P=0.036),而其他任务相关性均不显著;所有任务中血压调节速度均快于血流,且差异有统计学意义(P<0.05),其中,大腿袖带加压任务差异最显著(t=8.926,P<0.001);积分分析显示,大腿袖带加压(r=0.55,P=0.016)和主动站立任务(r=0.45,P=0.022)存在显著正相关。这些发现提示血压调节系统具有更快的响应特性。结论本研究通过多任务范式分析了血压与脑部血流的关系,可为量化脑血流自动调节提供实验依据,为未来对脑血流自动调节机制的量化研究提供先验性的参考。Objective To explore the interaction between cerebral blood flow microcirculation,blood pressure and cerebral autoregulation.Methods Twenty healthy adult subjects were recruited to complete four experimental tasks:upright tilt task,thigh cuff compression task,active standing task and squatting task to induce simultaneous changes of capillary blood flow and blood pressure in the brain.Cerebral blood flow was measured by diffuse correlation spectroscopy,blood pressure was recorded in real time by fingertip blood pressure recording technology,and the data frequency was matched by integer algorithm to ensure the consistency of data processing.In addition,the dynamic changes of blood flow and blood pressure were evaluated quantitatively by setting reaction time,response change rate,integral.Results In the active standing task,blood pressure and blood flow showed significant positive correlation(r=0.65,P=0.036),but no significant correlation was found in other tasks.The speed of blood pressure adjustment in all tasks was faster than that of blood flow,the difference was statistically significant(P<0.05),and the difference of thigh cuff compression task was the most significant(t=8.926,P<0.001).Integral analysis showed a significant positive correlation between thigh cuff compression(r=0.55,P=0.016)and active standing task(r=0.45,P=0.022).These findings suggested that the blood pressure regulation system had a faster response characteristic.Conclusion This study analyzes the relationship between blood pressure and cerebral blood flow through the multi-task paradigm,which can provide experimental basis for quantifying cerebral blood flow autoregulation and provide a priori reference for future quantitative research on cerebral blood flow autoregulation mechanism.

关 键 词：脑部微血流 血压 脑血流自动调节 漫射相关光谱 N阶线性算法 深层组织 

分 类 号：R197.39[医药卫生—卫生事业管理]