呼出气丙泊酚监测技术的研究进展  

Research Progress in Exhaled Breath Propofol Monitoring Techniques

作　　者：赵麟茜 陈星[3] 余启文 王菲 程珍珍 张冯江[2] ZHAO Linqian;CHEN Xing;YU Qiwen;WANG Fei;CHENG Zhenzhen;ZHANG Fengjiang(Department of Anesthesiology,The Fourth Affiliated Hospital,Zhejiang University School of Medicine,Yiwu Zhejiang 322000,China;Department of Anesthesiology,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou Zhejiang 310009,China;School of Biomedical Engineering and Instrument Science,Zhejiang University,Hangzhou Zhejiang 310030,China;Research Center for Frontier Fundamental Studies,Zhejiang lab,Hangzhou Zhejiang 311121,China)

机构地区：[1]浙江大学医学院附属第四医院麻醉科,浙江义乌322000 [2]浙江大学医学院附属第二医院麻醉科,浙江杭州310009 [3]浙江大学生物医学工程与仪器科学学院,浙江杭州310030 [4]之江实验室前沿基础研究中心,浙江杭州311121

出　　处：《中国医疗设备》2025年第4期144-150,共7页China Medical Devices

基　　金：浙江省自然科学基金(LY23H090015);医疗服务与保障能力提升-麻醉临床重点专科(2021-LCZDZK-01)。

摘　　要：丙泊酚是临床最常用的静脉麻醉剂,广泛应用于手术室和重症监护室等医疗环境中。但丙泊酚应用过量或不足均会引起围手术期及长期不良反应,因此,能够直接、无创、可靠监测丙泊酚血药浓度的手段十分重要。区别于其他静脉麻醉剂,丙泊酚具有非常高的蒸汽压。丙泊酚的高蒸汽压使其能够在呼出气中被检测,且其呼出气浓度可以反映血药浓度,这使得无创监测丙泊酚血药浓度成为可能。本文就不同呼出气丙泊酚监测技术的研究进展进行综述,归纳了目前该技术存在的问题,并对未来研究方向和发展趋势进行展望,以期为临床合理应用丙泊酚、提升麻醉安全性及优化相关监测技术提供参考。Propofol is the most frequently used intravenous anesthetic in clinical practice and is extensively applied in medical environments such as operating rooms and intensive care units.However,both over-administration and under-administration of propofol can induce perioperative and long-term adverse effects.Thus,it is of great significance to possess direct,non-invasive,and reliable methods for monitoring the blood concentration of propofol.Different from other intravenous anesthetics,propofol has an extremely high vapor pressure.This high vapor pressure enables its detection in exhaled breath,and the concentration of propofol in exhaled breath can mirror its blood concentration,rendering non-invasive monitoring of propofol blood levels feasible.This paper reviewed the research progress of various exhaled-breath propofol monitoring technologies,summarized the existing problems of these technologies,and forecasted the future research directions and development trends,with the aim of providing references for the rational clinical application of propofol,enhancing the safety of anesthesia,and optimizing the relevant monitoring technologies.

关 键 词：丙泊酚 静脉麻醉 呼出气浓度 麻醉监测 血药浓度 无创监测 

分 类 号：R614[医药卫生—麻醉学]