花瓣结构电极用于脉冲消融下心肌组织消融效果研究  

Simulation Study of Myocardial Tissue Ablation Effects Using Flower Petal-Structured Electrodes in Pulsed Ablation

作　　者：陆凌峰 陈惠铭 LU Lingfeng;CHEN Huiming(Shanghai Institute of Medical Device Testing,Shanghai,201318;NMPA Key Laboratory for Medical Electrical Equipment,Shanghai,201318)

机构地区：[1]上海市医疗器械检验研究院,上海市201318 [2]国家药品监督管理局医用电气设备重点实验室,上海市201318

出　　处：《中国医疗器械杂志》2025年第2期125-133,共9页Chinese Journal of Medical Instrumentation

摘　　要：该研究旨在评估花瓣结构电极在脉冲电场消融(pulsed field ablation,PFA)技术中的应用效果,特别是其在心肌组织消融中的表现。通过将仿真技术与体外实验相结合,探讨了不同电压、电极与组织接触距离对消融深度、连续性及透壁效果的影响。研究方法包括构建心肌组织仿真模型,使用COMSOL Multiphysics进行电场分布仿真,并进行马铃薯组织的体外消融实验。结果表明,随着电压的增大,消融深度显著增加;当电压达到2500 V时,能够实现4 mm的透壁消融深度,且消融区域较为连续。体外实验验证了仿真结果的一致性,且脉冲电场消融未引起显著温升,证实了其非热特性。结论指出,PFA技术具有较低的电极接触要求和较高的消融效率,为临床治疗房颤提供了新的技术路径,能够有效降低传统消融技术的并发症风险。This study aims to evaluate the application of flower petal-structured electrodes in pulsed field ablation(PFA)technology,with a particular focus on their performance in myocardial tissue ablation.Through a combination of simulation techniques and in vitro experiments,the study investigates the effects of different voltage levels,electrode-to-tissue contact distances,and their impact on ablation depth,continuity,and transmurality.The research methods include the construction of a myocardial tissue simulation model,electric field distribution simulation using COMSOL Multiphysics,and in vitro ablation experiments on potato tissue.The results indicate that as voltage increases,the ablation depth significantly increases.At a voltage of 2500 V,a transmural ablation depth of 4 mm can be achieved,and the ablation area remains relatively continuous.The in vitro experiments confirm the consistency of the simulation results,and pulsed field ablation does not induce significant temperature rise,confirming its non-thermal characteristic.The conclusion suggests that PFA technology requires less electrode contact and offers higher ablation efficiency,providing a new technological pathway for the clinical treatment of atrial fibrillation and effectively reducing the risk of complications associated with traditional ablation techniques.

关 键 词：房颤 脉冲电场消融 花瓣结构 心肌组织 

分 类 号：R318[医药卫生—生物医学工程]