气相色谱法测定交联多糖凝胶中残留溶剂二甲亚砜  

Determination of Residual Solvent Dimethyl Sulfoxide in Crosslinked Polysaccharide Gel by Gas Chromatography

作　　者：王宝群 陈醒 林莎莎 孙文昕 邹圣灿 WANG Baoqun;CHEN Xing;LIN Shasha;SUN Wenxin;ZOU Shengcan(Qingdao Chenlan Marine Biological Engineering Co.,Ltd.,Shandong Qingdao 266000,China)

机构地区：[1]青岛琛蓝海洋生物工程有限公司,山东青岛266000

出　　处：《广州化工》2025年第7期109-111,124,共4页GuangZhou Chemical Industry

摘　　要：以色谱级甲醇为溶剂,建立了高灵敏度、高精确度的气相色谱法测定交联多糖凝胶中有机溶剂二甲亚砜(DMSO)的残留量。采用DB-FFAP毛细管柱(30 m×0.32 mm×0.5μm)分离样品,柱温采用程序升温方式,氢火焰离子化(FID)检测器,检测器温度为250℃,进样口温度为220℃,分流比为30∶1,进样量1μL。二甲亚砜与溶剂峰完全分离,DMSO在0.1~10μg/m L浓度范围内线性关系良好(r^(2)=0.999 1),平均回收率为99.97%。该方法灵敏度高、重复性好,可用于测定交联多糖凝胶中低残留量的有机溶剂二甲亚砜。A high-sensitivity and high-accuracy gas chromatography method was developed for the determination of dimethyl sulfoxide(DMSO)residues in crosslinked polysaccharide gel using chromatographic-grade methanol as solvent.Samples were separated by a DB-FFAP capillary column(30 m×0.32 mm×0.5μm),and the temperature of the column was temperatune-programmed A flame ionization detector(FID)was operated at 250℃with a split ratio of 30∶1,and the inlet temperature was maintained at 220℃.The injection volume was 1μL.DMSO was completely resolved from the solvent peak,demonstrating a linear relationship(r^(2)=0.9991)across the concentration range of 0.1 to 10μg/mL.The average recovery reached 99.97%.This method featured high sensitivity and good repeatability,making it suitable for determining trace DMSO residues in crosslinked polysaccharide gels.

关 键 词：气相色谱法 交联多糖凝胶 二甲亚砜 高灵敏度 

分 类 号：TQ433.9[化学工程]