注射用阿莫西林钠克拉维酸钾在小儿肺炎中的应用效果分析  

Analysis of the application effect of amoxicillin sodium and clavulanate potassium for injection in pediatric pneumonia

作　　者：张小敏 ZHANG Xiao-min(Jinxiang County People's Hospital,Jining 272200,China)

机构地区：[1]金乡县人民医院,272200

出　　处：《中国实用医药》2025年第6期6-10,共5页China Practical Medicine

摘　　要：目的 探讨注射用阿莫西林钠克拉维酸钾在小儿肺炎中的应用效果。方法 选取100例肺炎患儿,按照盲选方式分为对照组(常规治疗)、观察组(常规治疗+注射用阿莫西林钠克拉维酸钾治疗),各50例。比较两组治疗效果、不良反应发生情况、症状缓解时长、住院所需时长、炎症因子水平及肺功能指标。结果 观察组总有效率(96.00%)高于对照组(84.00%),比较存在差异(P<0.05)。两组不良反应发生率比较无明显差异(P>0.05)。观察组住院所需时长、咳嗽缓解时长、肺部湿啰音消失时长、发热消失时长、痰鸣音消失时长分别为(6.46±1.63)、(1.37±0.38)、(4.17±1.12)、(4.66±1.35)、(3.99±0.97)d,均短于对照组的(8.45±2.07)、(2.55±0.62)、(5.26±1.44)、(5.78±1.59)、(4.75±1.14)d,比较存在差异(P<0.05)。观察组治疗后的白细胞介素-6、C反应蛋白、肿瘤坏死因子-α分别为(9.65±1.71)pg/ml、(6.55±1.02)mg/L、(11.49±2.24)pg/ml,均低于对照组的(13.92±2.43)pg/ml、(10.21±2.69)mg/L、(15.15±2.37)pg/ml,比较存在差异(P<0.05)。观察组治疗后的用力肺活量、第1秒用力呼气容积分别为(2.85±0.61)、(2.59±0.58)L,均高于对照组的(2.32±0.53)、(1.99±0.47)L,比较存在差异(P<0.05)。结论 在常规治疗方案基础上加用注射用阿莫西林钠克拉维酸钾治疗肺炎患儿可增强疗效,用药安全价值高,利于患儿更快缓解症状,且炎症因子水平和肺功能均得以改善。Objective To explore the application effect of amoxicillin sodium and clavulanate potassium for injection in pediatric pneumonia.Methods 100 pediatric patients with pneumonia were selected and divided into control group(conventional treatment) and observation group(conventional treatment + amoxicillin sodium and clavulanate potassium for injection) by blind selection,each consisting of 50 patients.The treatment effect,occurrence of adverse reactions,duration of symptom remission and hospitalization,levels of inflammatory factors and lung function index were compared between the two groups.Results The total effective rate of the observation group(96.00%) was higher than that of the control group(84.00%),and there was a difference(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).In the observation group,the duration of hospitalization,the duration of cough relief,the duration of lung wet rales,the duration of fever and the duration of wheezy phlegm were(6.46±1.63),(1.37±0.38),(4.17±1.12),(4.66±1.35) and(3.99±0.97) d,which were shorter than(8.45±2.07),(2.55±0.62),(5.26±1.44),(5.78±1.59) and(4.75±1.14) d in the control group,and there were differences(P<0.05).After treatment,the levels of interleukin-6,C-reactive protein and tumor necrosis factor-α were(9.65±1.71) pg/ml,(6.55±1.02) mg/L and(11.49±2.24) pg/ml in the observation group,which were lower than(13.92±2.43) pg/ml,(10.21±2.69) mg/L and(15.15±2.37) pg/ml in the control group,and there were differences(P<0.05).After treatment,the forced vital capacity and forced expiratory volume in one second in the observation group were(2.85±0.61) and(2.59±0.58) L,which were higher than(2.32±0.53) and(1.99±0.47) L in the control group,and there were differences(P<0.05).Conclusion For the treatment of pediatric pneumonia,the addition of moxicillin sodium and clavulanate potassium for injection over the conventional treatment is more valuable than conventional therapy,which is conducive to the

关 键 词：小儿肺炎 注射用阿莫西林钠克拉维酸钾 治疗效果 肺功能 

分 类 号：R725.6[医药卫生—儿科]