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作 者:王志军[1] WANG Zhi-jun(Department of Pediatrics,Baotou Central Hospital,Baotou 014040,China)
机构地区:[1]包头市中心医院儿科,014040
出 处:《中国实用医药》2025年第6期38-41,共4页China Practical Medicine
摘 要:目的 探讨支气管镜肺泡灌洗辅助治疗小儿重症肺炎支原体肺炎(SMPP)的临床效果及对其炎性因子和肺功能的影响。方法 将72例SMPP患儿随机分为对照组和观察组,每组36例。对照组使用常规治疗,观察组在对照组治疗基础上使用支气管镜肺泡灌洗辅助治疗。比较两组临床疗效、治疗前后炎性因子[C反应蛋白(CRP)、红细胞沉降率(ESR)、白细胞介素-6(IL-6)、D-二聚体(D-D)]及肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、最大呼气流量(PEF)、最大呼气中段流量(MMEF)]。结果 观察组治疗总有效率高达97.22%,较于对照组的72.22%明显提升(P<0.05)。治疗后,观察组CRP、ESR、IL-6、D-D水平分别为(4.23±0.92)mg/L、(51.49±7.84)mm/h、(18.63±4.04)ng/L、(1.12±0.16)mg/L,均低于对照组的(11.65±2.03)mg/L、(63.38±8.83)mm/h、(27.75±5.96)ng/L、(1.87±0.25)mg/L(P<0.05)。治疗后,观察组FEV1、FVC、PEF、MMEF水平分别为(1.95±0.30)L、(2.26±0.27)L、(3.56±0.53)L/s、(1.70±0.41)L/s,均大于对照组的(1.71±0.24)L、(1.89±0.23)L、(2.98±0.46)L/s、(1.46±0.38)L/s(P<0.05)。结论 支气管镜肺泡灌洗辅助治疗对小儿SMPP的临床效果显著,能提高抗炎作用,有效改善肺功能。Objective To explore the clinical effect of bronchoscopic alveolar lavage adjuvant therapy on severe Mycoplasma pneumoniae pneumonia(SMPP) in children and its influence on inflammatory factors and lung function.Methods 72 children with SMPP were randomly divided into control group and observation group,with 36 cases in each group.The control group received conventional treatment,and the observation group received bronchoscopic alveolar lavage adjuvant therapy in addition to the control group.Comparison of clinical efficacy,inflammatory factors [C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),interleukin-6(IL-6),D-dimer(D-D)] and lung function indexes [forced expiratory volume in one second(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF),and maximum mid-expiratory flow(MMEF)] before and after treatment between the two groups.Results The total effective rate of the observation group was 97.22%,which was significantly higher than 72.22% of the control group(P<0.05).After treatment,the levels of CRP,ESR,IL-6 and D-D in the observation group were(4.23±0.92) mg/L,(51.49±7.84) mm/h,(18.63±4.04) ng/L and(1.12±0.16) mg/L,which were lower than(11.65±2.03) mg/L,(63.38±8.83) mm/h,(27.75±5.96) ng/L and(1.87±0.25) mg/L in the control group(P<0.05).After treatment,the levels of FEV1,FVC,PEF and MMEF in the observation group were(1.95±0.30) L,(2.26±0.27) L,(3.56±0.53) L/s and(1.70±0.41) L/s,which were greater than(1.71±0.24) L,(1.89±0.23) L,(2.98±0.46) L/s and(1.46±0.38) L/s in the control group(P<0.05).Conclusion Bronchoscopic alveolar lavage adjuvant therapy has significant clinical effect on children with SMPP,and can improve the antiinflammatory effect and effectively enhance the lung function.
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