CEA、CA19-9联合脱落细胞学在良恶性胸腔积液诊断中的价值  

Value of CEA and CA19-9 combined with exfoliative cytology in diagnosis of benign and malignant pleural effusions

作　　者：徐庆华[1] 舒向芳[1] 曲惠青[2] XU Qing-hua;SHU Xiang-fang;QU Hui-qing(Boxing County People's Hospital,Binzhou 256500,China)

机构地区：[1]博兴县人民医院,256500 [2]滨州医学院附属医院,256600

出　　处：《中国实用医药》2025年第6期81-83,共3页China Practical Medicine

摘　　要：目的 探讨癌胚抗原(CEA)、糖类抗原19-9(CA19-9)检测联合脱落细胞学检查在良、恶性胸腔积液鉴别诊断中的临床意义。方法 选取恶性肿瘤患者的胸腔积液标本42例为恶性组,另选取良性胸腔积液标本38例为良性组。两组均采用电化学发光法检测胸腔积液中CEA、CA19-9水平,同时进行胸腔积液脱落细胞学检查。比较两组胸腔积液中CEA、CA19-9水平,CEA、CA19-9、脱落细胞学阳性率。结果 恶性组胸腔积液CEA和CA19-9水平分别为(301.10±193.10)ng/ml、(96.10±88.30)U/ml,均明显高于良性组的(2.68±0.98)ng/ml、(19.68±16.75)U/ml,差异有统计学意义(P<0.05)。恶性组脱落细胞学、CEA、CA19-9阳性率分别为57.1%、81.0%、69.0%,均明显高于良性组的0、10.5%、7.9%,差异有统计学意义(P<0.05)。结论 CEA、CA19-9联合脱落细胞学检测可以提高良、恶性胸腔积液的诊断准确性,值得在临床上推广应用。Objective To explore the clinical significance of carcinoembryonic antigen(CEA) combined with carbohydrate antigen 19-9(CA19-9) in diagnosis of benign and malignant pleural effusions.Methods 42 specimens of pleural effusion from patients with malignant tumors were selected as the malignant group,and 38 specimens of benign pleural effusion were selected as the benign group;the CEA and CA19-9 levels in pleural effusion were detected by electrochemiluminescence,and exfoliative cytology in the corresponding pleural effusion was performed.The levels of CEA,CA19-9 in pleural effusion and the positive rates of CEA,CA19-9 and exfoliative cytology were compared between the two groups.Results The levels of CEA and CA19-9 in pleural effusion were(301.10±193.10) ng/ml and(96.10±88.30) U/ml in malignant group,which were significantly higher than(2.68±0.98) ng/ml and(19.68±16.75) U/ml in benign group,and the difference was statistically significant(P<0.05).The positive rates of exfoliative cytology,CEA and CA19-9 in malignant group were 57.1%,81.0% and 69.0%,which were significantly higher than 0,10.5% and 7.9% in benign group,and the difference was statistically significant(P<0.05).Conclusion CEA and CA19-9 combined with exfoliative cytology can improve the diagnostic accuracy of benign and malignant pleural effusions,and is worth popularizing in clinical practice.

关 键 词：癌胚抗原 糖类抗原19-9 脱落细胞学 胸腔积液 良恶性 鉴别诊断 

分 类 号：R446.1[医药卫生—诊断学] R730.43[医药卫生—临床医学]