股骨粗隆间骨折术中使用氨甲环酸对围术期失血量的影响  

Clinical medication effects of intraoperative tranexamic acid use on perioperative blood loss in intertrochanteric fractures of the femur

作　　者：陈镇鑫 郑宁[1] 陈义藩[1] 刘俊波[1] 李裕祥[1] 江洪耿 CHEN Zhen-Xin;ZHENG Ning;CHEN Yi-Fan(Department of Orthopaedic SurgeryⅠ,Jieyang People's Hospital,Jieyang 522000,Guangdong,China)

机构地区：[1]揭阳市人民医院骨外一科,广东揭阳522000

出　　处：《吉林医学》2025年第4期915-918,共4页Jilin Medical Journal

基　　金：揭阳市卫健局医学科学技术研究项目[项目编号:揭市卫(2021)57号167]。

摘　　要：目的:研究股骨粗隆间骨折术中使用氨甲环酸对围术期失血量的影响。方法:选取揭阳市人民医院收治的138例股骨粗隆间骨折患者作为研究对象,随机分为研究组和对照组各69例。对照组术中给予生理盐水,不使用氨甲环酸治疗,研究组术中给予氨甲环酸进行治疗。比较两组患者手术时长等一般资料。于入院时、术前及术后1 d、3 d进行血常规检查并记录相关数据,计算术前、术后1 d、术后3 d失血量、显性失血量、术前及术后隐性失血量,并记录两组并发症发生情况,对相关数据组间差异进行对比分析。结果:研究组术后1 d、3 d失血量均显著低于对照组,差异有统计学意义(P<0.05);研究组显性失血量及术后隐性失血量均低于对照组,差异有统计学意义(P<0.05);两组术后并发症发生率比较,差异无统计学意义(P>0.05)。结论:股骨粗隆间骨折手术术中使用氨甲环酸可有效减少患者术后不同时间失血量及显性失血量,临床疗效显著。Objective To study the effect of intraoperative tranexamic acid on perioperative blood loss in trochanteric femoral fractures.Methods A total of 138 patients withintertrochanteric fracture of the femur admitted to the Jieyang People's Hospital between July 2021 and October 2023 were randomly divided into a control group and a study group,with 69 patients in each group.The control group did not receive tranexamic acid during surgery,while the study group did.We compared general information on surgery duration between the two groups.Blood tests were conducted at admission,preoperatively,and on postoperative days 1 and 3.Data on blood loss,apparent blood loss,and occult blood loss before and after surgery were recorded and calculated.The incidence of complications in both groups was documented and compared.Results The amount of blood loss in the study group was significantly lower than that in the control group in 1 d and 3 d postoperatively,which was comparable(P<0.05);the amount of dominant blood loss and postoperative occult blood loss in the study group was lower than that in the control group,which was comparable(P<0.05);the incidence of postoperative complications in the study group was 8.70%,and that in the control group was 10.14%,and there was no statistically significant difference between the two groups in terms of the incidence of complications(P>0.05).Conclusions The intraoperative use of tranexamic acid in femur intertrochanteric fracture surgery can effectively reduce the amount of blood loss at different times and the amount of significant blood loss in the postoperative period of patients,and the clinical efficacy is remarkable.

关 键 词：股骨骨折 失血量 氨甲环酸 术后并发症 

分 类 号：R683.42[医药卫生—骨科学]