2-羟基-5-壬基苯乙酮(HNA)酯化工艺优化  

Optimization of 2-hydroxy-5-nonylacetophenone(HNA)Esterification Process

作　　者：李丽淋 杨旺海 徐创亮 葛雪惠 Li Lilin;Yang Wanghai;Xu Chuangliang;Ge Xuehui(College of Chemical Engineering,Fuzhou University,Fujian,350108;Fujian Zijin Mineral Processing Pharmacy Co.,Ltd.,Fujian,361000)

机构地区：[1]福州大学化工学院,福建350108 [2]福建紫金选矿药剂有限公司,福建361000

出　　处：《当代化工研究》2025年第6期154-156,共3页Modern Chemical Research

基　　金：福建省科技厅资助项目“铜萃取剂苯乙酮肟合成及铜微萃取技术开发”(项目编号:2021Y0007);福州大学研究生教育教学改革项目“《化工数学方法》精品课程建设项目”(项目编号:FYKC2023005)。

摘　　要：针对2-羟基-5-壬基苯乙酮肟(HNAO)合成过程中酯化重排步骤出现的转化率低,生成大量副产物等问题,实验中采用了两步法工艺,以壬基酚、乙酸酐、无水三氯化铝和盐酸为主要原料,通过改变反应物投料质量,优化合成了2-羟基-5-壬基苯乙酮(HNA),使得反应液中HNA纯度由55%提升至68%。通过精馏可以得到纯度为95%~98%的2-羟基-5-壬基苯乙酮产品。In view of the low conversion rate and a large number of by-products in the esterification reordering step during the synthesis of 2-hydroxy-5-nonylacetophenone oxime(HNAO),the traditional two-step method was adopted in the experiments.Nonylphenol,acetic anhydride,anhydrous aluminum trichloride and hydrochloric acid were used as the main raw materials.The synthesis of 2-hydroxy-5-nonylacetophenone(HNA)was optimized by changing the quality of the reactant feed,which led to an increase in the purity of HNA in the reaction solution from 55%to 68%.The product of 2-hydroxy-5-nonylacetophenone with purity of 95%~98%can be obtained by distillation.

关 键 词：2-羟基-5-壬基苯乙酮 间歇精馏 酯化 FRIES重排 

分 类 号：TQ2[化学工程—有机化工]