Water-stable Metal-Organic Framework for Hyperpolarized Xenon MRI in Aqueous Solution  

作　　者：ZENG Qingbin WANG Zhen GUO Qianni SONG Wei ZHAO Xiuchao YANG Yuqi ZHOU Xin 

机构地区：[1]State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging,National Center for Magnetic Resonance in Wuhan,Wuhan Institute of Physics and Mathematics,Innovation Academy for Precision Measurement Science and Technology,Chinese Academy of Sciences,Wuhan 430071,P.R.China [2]University of Chinese Academy of Sciences,Bejing 100049,P.R.China

出　　处：《Chemical Research in Chinese Universities》2025年第2期305-312,共8页高等学校化学研究(英文版)

基　　金：supported by the National Natural Science Foundation of China(Nos.82127802,21921004);the Strategic Priority Research Program of CAS(No.XDB0540000);the Key Research Program of Frontier Sciences of CAS(No.ZDBS-LY-JSC004);the Key Technology Foundation of Hubei Province,China(No.2021ACA013);the Major Program(JD)of Hubei Province,China(No.2023BAA021);the CAS Fund for the Youth Interdisciplinary Team,China(No.JCTD-2022-13);the Youth Innovation Promotion Association of CAS(No.2023347);Wuhan Talent Project,China and the Natural Science Foundation of Hubei Province,China(No.2023AFB790).

摘　　要：Hyperpolarized 129Xe magnetic resonance imaging(MRI)is a powerful tool for detecting respiratory system diseases.However,129Xe is an inert gas and lacks specific detection capability.Entrapping xenon within molecular cages to enable specific detection is a challenging task,and numerous molecular cages have been developed and evaluated to address this challenge.Herein,we report that the aluminum-based metal-organic framework,CAU-1,can effectively entrap xenon for hyperpolarized 129Xe MRI in aqueous solutions.This platform exhibits high water stability and good dispersibility,and shows excellent xenon entrapment capability,even at a concentration as low as 50µg/mL.Importantly,it is responsive to pH changes across a range from 6.6 to 5.0,making it promising for monitoring the weakly acidic environment in tumors or metabolic abnormality.Furthermore,the scalable and cost-effective production of this molecular cage will facilitate future advancements in molecular imaging and chemical sensing applications.

关 键 词：Metal-organic framework(MOF) HYPERPOLARIZATION Magnetic resonance imaging(MRI) 

分 类 号：O641[理学—物理化学]