色谱技术在手性药物分离研究中的应用  

Application of Chromatographic Technology in Chiral Drug Separation Research

作　　者：刘流 姚平 张周菊 Liu Liu;Ping Yao;Zhouju Zhang(Hubei Liyi Pharmaceutical Technology Co.,Ltd.,Wuhan,Hubei 430000)

机构地区：[1]湖北丽益医药科技有限公司,湖北武汉430000

出　　处：《医学研究前沿》2025年第3期17-19,共3页Frontiers of Medical Research

摘　　要：手性药物在药物研发、临床治疗和药品监管中至关重要。其分子中的手性中心导致不同对映体药效和毒性各异,因此需有效分离纯化。色谱技术作为成熟高效的分离手段,广泛应用于手性药物分离。该技术通过利用吸附、分配、离子交换等机制在固定相和流动相中的行为差异实现分离,具有高效性、高选择性、高分辨率及操作简便等优点,成为手性药物分离领域的关键技术。Chiral drugs are crucial in drug development,clinical treatment,and drug regulation.The chiral center in its molecule results in varying pharmacological and toxic effects for different enantiomers,thus requiring effective separation and purification.Chromatography technology,as a mature and efficient separation method,is widely used in the separation of chiral drugs.This technology achieves separation in the stationary and mobile phases by utilizing mechanisms such as adsorption,distribution,and ion exchange.It has the advantages of high efficiency,high selectivity,high resolution,and easy operation,and has become a key technology in the field of chiral drug separation.

关 键 词：色谱技术 手性药物 分离研究 

分 类 号：R917[医药卫生—药物分析学]