Black Phosphorus and E7-Functionalized Sulfonated Polyetheretherketone with Effective Osteogenicity and Antibacterial Activity  

作　　者：Xiao Wang Shuning Zhang Ai Zhu Lingyan Cao Long Xu Junjie Wang Fei Zheng Xiangkai Zhang Hongyan Chen Xinquan Jiang 

机构地区：[1]Department of Prosthodontics,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,Shanghai 200011,China [2]National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai Engineering Research Center of Advanced Dental Technology and Materials,Shanghai 200011,China [3]Institute of Translational Medicine,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Engineering》2025年第3期147-161,共15页工程(英文)

基　　金：support by the Fundamental Research Funds for the Central Universities(YG2024QNB16);the National Natural Science Foundation of China(82270953 and 82201115);Shanghai Rising-Star Program(21QA1405400);the Natural Science Foundation of Shanghai(22ZR1436400);the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZLCX20212400);the Opening Research fund from Shanghai Key Laboratory of Stomatology,Shanghai Ninth People’s Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine(2022SKLS-KFKT008).

摘　　要：Given its excellent biological properties and the matching of its elastic modulus with that of human bone tissue,medical polyetheretherketone(PEEK)is considered a desirable candidate for bone-implant materials.However,its poor osseointegrative and antibacterial properties greatly limit its clinical application.To address these concerns,a functional PEEK implant is needed.Herein,a novel photo-responsive multifunctional PEEK-based implant material(sPEEK/BP/E7)with both effective osteogenesis and good disinfection properties was constructed via the self-assembly of black phosphorus(BP)nanosheets,mussel-inspired polydopamine(PDA),and bioactive short peptide E7 on sulfonated PEEK(sPEEK).The versatile micro-/nano-structured PEEK surface provides superior hydrophilicity,a favorable osteogenic microenvironment,and excellent photothermal effects under near-infrared(NIR)irradiation.The in vitro results showed that sPEEK/BP/E7 displays enhanced cytocompatibility and osteogenicity in terms of cell adhesion,proliferation,alkaline phosphatase(ALP)activity,matrix mineralization,and osteogenesis-related gene expression,superior to those of the sPEEK and sPEEK/BP samples.In addition to osteogenesis,the multifunctional coating exhibited strong antibacterial activity against both Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli).Furthermore,it was confirmed in a rat femoral infection model that sPEEK/BP/E7 effectively resisted infection caused by S.aureus under NIR light irradiation and promoted osseointegration in vivo.Thus,this work presents a facile strategy to realize improvement of the“functional integration”of new polymer bone–implant materials and provide new ideas for their clinical application.

关 键 词：POLYETHERETHERKETONE Black phosphorus nanosheets E7 peptides Stem cell recruitment Osteogenesis Antibacterial 

分 类 号：R318.08[医药卫生—生物医学工程] R318[医药卫生—基础医学]