炎症反射在脓毒症器官损伤发生发展中的作用研究进展  

Role of the inflammatory reflex in the development and progression of organ injury in sepsis:a review

作　　者：周新越 王妍[1] 方向明[1] Zhou Xinyue;Wang Yan;Fang Xiangming(Department of Anesthesiology,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第一医院麻醉科,杭州310003

出　　处：《中华创伤杂志》2025年第3期318-324,共7页Chinese Journal of Trauma

基　　金：国家自然科学基金(82302410)。

摘　　要：脓毒症是指由感染引起的机体反应异常而导致危及生命的器官功能障碍,是导致患者死亡的主要病因之一,至今仍缺乏有效的预警和治疗技术。近年来,神经与免疫系统交互作用对脓毒症发生发展的影响颇受关注,但脓毒症引发脏器损伤的具体机制及器官交互作用等问题仍不明确。炎症反射即中枢神经系统整合传入的炎症信号并对外周炎症反应产生反射性调节,是中枢神经网络调控外周免疫的重要起点。通过调控炎症反射进而改善其免疫功能紊乱将是治疗脓毒症的突破点。然而,脓毒症中炎症反射如何引起机体中枢神经系统及外周免疫系统改变,以及炎症反射如何参与脓毒症中的器官损伤仍有待探讨。为此,笔者对炎症反射在脓毒症器官损伤发生发展中的作用研究进展进行综述,以期为脓毒症治疗提供新思路。Sepsis,a life⁃threatening organ dysfunction caused by an abnormal host response to infection,remains one of the leading causes of mortality in critically ill patients,but there is currently a lack of effective early warning systems and therapeutic strategies for sepsis.In recent years,the interaction between the nervous and immune systems has gained considerable attention.However,the precise mechanisms underlying sepsis⁃related organ damage and the complex interplay among different organs remain poorly understood.The inflammatory reflex,which involves the central nervous system integrating incoming inflammatory signals and reflexively modulating peripheral inflammatory responses,is a critical interface where the central nervous network regulates peripheral immunity.Modulating the inflammatory reflex to correct immune dysfunction may represent a promising therapeutic breakthrough for sepsis.Nevertheless,the precise mechanisms by which the inflammatory reflex induces changes in both the central nervous system and the peripheral immune system in sepsis,as well as its role in organ damage,remain to be elucidated.To this end,the authors reviewed the researches on the role of the inflammatory reflex in the development and progression of sepsis⁃related organ damage,aiming to provide novel insights into more effective therapeutic strategies for sepsis.

关 键 词：脓毒症 神经免疫调节 下丘脑⁃垂体系统 炎症反射 

分 类 号：R826.3[医药卫生—临床医学] R364.5R392.3