尿酸对女性生育力及辅助生殖助孕结局的影响  

Impact of uric acid on female fertility and the pregnancy outcomes of assisted reproductive technology

作　　者：张珺 黄铄[1] 石婧 刘琼 韩栋林 余晓君 赵捷 Zhang Jun;Huang Shuo;Shi Jing;Liu Qiong;Han Donglin;Yu Xiaojun;Zhao Jie(Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital),Key Laboratory of Assisted Reproduction(Peking University),Ministry of Education,Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology,Beijing 100191,China;Department of Pharmacy,Peking University Third Hospital,Beijing 100191,China;Department of Nutrition and Food Hygiene,School of Public Health,Kunming Medical University,Kunming 650500,China)

机构地区：[1]北京大学第三医院妇产科生殖医学中心、国家妇产疾病临床医学研究中心(北京大学第三医院)辅助生殖教育部重点实验室(北京大学),北京市生殖内分泌与辅助生殖技术重点实验室,北京100191 [2]北京大学第三医院药学系,北京100191 [3]昆明医科大学公共卫生学院营养与食品卫生学教研室,昆明650500

出　　处：《中华生殖与避孕杂志》2025年第3期305-309,共5页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金(82271863);北京大学第三医院院临床重点项目(BYSYZD2023007)。

摘　　要：尿酸是人体内嘌呤物质代谢的最终产物。近年来,尿酸在女性生育力与辅助生殖技术中的作用引起了研究者的关注。尿酸代谢障碍会导致高尿酸血症(hyperuricemia,HUA)。HUA不仅与代谢综合征、心血管疾病密切相关,还可能通过影响卵巢功能、胚胎发育等机制对女性的生育力产生不良影响。本文重点探讨了尿酸在女性生育力中的作用,包括尿酸与女性低生育力、不孕症、不良妊娠结局、代谢综合征等之间的关系,以及在体外受精-胚胎移植和卵胞质内单精子注射助孕中的潜在影响。未来的研究应进一步明确育龄女性尿酸水平的界值及临床干预价值,为HUA育龄女性患者的生殖健康咨询及个体化助孕提供依据。Uric acid is the end product of purine metabolism in the human body.In recent years,the role of uric acid in female fertility and assisted reproductive technology(ART)has gained increasing attention.Dysregulation of uric acid metabolism can lead to hyperuricemia(HUA).HUA is not only closely related to metabolic syndrome and cardiovascular diseases but may also adversely affect female fertility by influencing ovarian function and embryos development.In this review,we explored the role of uric acid in female fertility,including its association with female subfertility,infertility,adverse pregnancy outcomes and metabolic syndrome,as well as its potential impact on ART like in vitro fertilization-embryo transfer and intracytoplasmic sperm injection.Further studies are needed to clarify the threshold and clinical intervention value of uric acid levels in women of childbearing age,providing a basis for reproductive health counseling and personalized pregnancy assistance for HUA patients of childbearing age.

关 键 词：尿酸 高尿酸血症 生育力 生殖技术 辅助 体外受精 妊娠结局 

分 类 号：R711.6[医药卫生—妇产科学]