基于“木郁土壅,痰瘀互结”探讨动脉粥样硬化与铁死亡的相关性  

Study on the correlation between atherosclerosis and iron death based on“stagnation of wood and earth,phlegm and blood stasis”

作　　者：张曼 王帅[2] Zhang Man;Wang Shuai(Liaoning University of Traditional Chinese Medicine,Shenyang,Liaoning 110847,China;First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang,Liaoning 110032,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学第一附属医院,辽宁沈阳110032

出　　处：《首都食品与医药》2025年第7期8-10,共3页Capital Food Medicine

基　　金：辽宁省自然基金项目(编号:2023-MS-230);沈阳市科技计划项目(编号:21-174-9-15);全国老中医药专家传承工作室项目;重大疾病治疗重点专科建设项目。

摘　　要：动脉粥样硬化(Atherosclerotic,AS)是脂质沉积于血管内皮,粥样硬化斑块形成,导致血管壁增厚和管腔狭窄的一种慢性炎症性改变。铁沉积与脂质过氧化物的积累为其特征表现,其促进了动脉粥样硬化的发生与发展。中医学认为脾失健运,肝体失养,疏泄不及,痰湿内生,日久生瘀,痰瘀互结,阻于脉道,导致动脉粥样硬化。因此,本文旨在探讨动脉粥样硬化“木郁土壅,痰瘀互结”的病机与铁死亡病理机制相关性,旨在为中医药靶向治疗动脉粥样硬化提供新的思路。Atherosclerotic(AS)is a chronic inflammatory change in which lipids are deposited in the vascular endothelium and atherosclerotic plaques are formed,leading to thickening of the vascular wall and narrowing of the lumen.Iron deposition and accumulation of lipid peroxides are its characteristics,which promote the occurrence and development of atherosclerosis.Traditional Chinese Medicine believes that the spleen loses its healthy function,the liver loses its nourishment,and it is not able to relieve itself.Phlegm and dampness are endogenous,and blood stasis are generated over time.Phlegm and blood stasis are intertwined,blocking the pulse channels,leading to atherosclerosis.Therefore,the purpose of this paper is to explore the correlation between the pathogenesis of atherosclerosis“stagnation of wood and earth,phlegm and blood stasis”and the pathological mechanism of iron death,and to provide a new idea for the targeted treatment of atherosclerosis with Traditional Chinese Medicine.

关 键 词：动脉粥样硬化 铁死亡 脂质过氧化 木郁土壅 

分 类 号：R256.2[医药卫生—中医内科学]