七叶皂苷钠与甘露醇治疗三踝骨折术前肢体肿胀的效果对比  

Comparative of Sodium Aescinate and Mannitol in Limb Swelling Before Trimalleolar Fracture Surgery

作　　者：杨子飞 吴雨桐 孙勇[1] 王东艳 王龄磊 张超[1] YANG Zifei;WU Yutong;SUN Yong;WANG Dongyan;WANG Linglei;ZHANG Chao(Department of Orthopedics,PLA 32268 Unit,Dali Yunnan 671000,China)

机构地区：[1]中国人民解放军32268部队骨科,云南大理671003

出　　处：《中国卫生标准管理》2025年第5期156-159,共4页China Health Standard Management

摘　　要：目的对比研究七叶皂苷钠与甘露醇在治疗三踝骨折术前肢体肿胀的临床效果。方法回顾性分析2021年1月—2023年1月在中国人民解放军32268部队骨科住院的三踝骨折术前肢体肿胀患者,随机抽取146份三踝骨折术前肢体肿胀患者资料,根据术前消肿药物的使用情况,分为七叶皂苷钠组(n=53)和甘露醇组(n=35)。七叶皂苷钠组和甘露醇组均予以骨折复位、持续跟骨牵引、消肿等治疗,甘露醇组消肿药物为20%浓度的甘露醇注射液,七叶皂苷钠组消肿药物为七叶皂苷钠注射液,比较两组患者的消肿时间和不良事件发生率。结果七叶皂苷钠组患者消肿时间为5.7(4.3,9.0)d,而甘露醇组患者消肿时间为8.0(6.1,10.2)d,七叶皂苷钠组消肿时间较短,差异有统计学意义(U=677.500,P=0.033)。治疗过程中七叶皂苷钠组不良事件总发生率为9.43%,甘露醇组不良事件总发生率为31.56%,七叶皂苷钠组不良事件总发生率高于甘露醇组,差异有统计学意义(P<0.05)。结论七叶皂苷钠治疗三踝骨折术前肢体肿胀的效果优于甘露醇,且不良事件发生率低。Objective To compare the clinical effects of sodium aescinate and mannitol in the treatment of limb swelling before trimalleolar fracture.Methods A retrospective analysis was performed on patients with limb swelling before trimalleolar fracture admitted to department of orthopedics,PLA 32268 Unit from January 2021 to January 2023,and 146 patients with limb swelling before trimalleolar fracture were randomly selected and divided into sodium aescinate group(n=53)and mannitol group(n=35)according to the use of antiswelling drugs before surgery.Both the sodium aescinate group and the mannitol group were treated with fracture reduction,continuous calcaneal traction and detumescence.The detumescence drug in the mannitol group was mannitol injection with 20% concentration, and the detumescence drug in the sodium aescinate group was sodium aescinate injection. The detumescence time and incidence of adverse events were compared between the two groups. Results The detumescence time of sodium aescinate group was 5.7 (4.3, 9.0) d, while that of mannitol group was 8.0 (6.1, 10.2) d, the detumescence time of sodium aescinate group was shorter, and the difference was statistically significant (U=677.500, P =0.033). The total incidence of adverse events was 9.43% in sodium aescinate group and 31.56% in mannitol group, the total incidence of adverse events in sodium aescinate group was higher than that in mannitol group, and the difference was statistically significant (P < 0.05). Conclusion Sodium aescinate is more effective than mannitol in the treatment of limb swelling before trimalleolar fracture surgery, and the incidence of adverse events is lower.

关 键 词：七叶皂苷钠 甘露醇 三踝骨折 肢体肿胀 不良事件 消肿时间 

分 类 号：R683[医药卫生—骨科学]