Aggregation-induced emission-based covalent-organic framework fluorescent probes for clinical detection of aluminum and daily prevention of Alzheimer's disease by naked-eye  

作　　者：Yun Zhao Enpeng Xi Ziwei Wang Qi Ding Kangning Liu Jinxing Zhu Xuhan Wu Yiling Xie Fuming Yang Nan Gao Hanjun Sun Yajie Yang Ye Yuan Guangshan Zhu 

机构地区：[1]Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education and Faculy of Chemistry.Northeast Normal University,Changchun 130024,China [2]School of Chemistry and Materials Science,Jiangsu Key Laboratory of New Power Batteries,Jiangsu Collaborative Innovation Centerof Biomedical Functional Materials,Nanjing Normal University,Nanjing 210023,China [3]Key Laboratory of Automobile Materials of Ministry of Education&School of Materials Science and Engineering,Jilin University Changchun 130022,China

出　　处：《Science China Chemistry》2025年第4期1326-1336,共11页中国科学(化学英文版)

基　　金：supported by the National Key R&D Program of China(2022YFB3805902);the National Natural Science Foundation of China(22131004,U21A20330,21975039 and 22077118);the“111”project(B18012);the Fundamental Research Funds for the Central Universities,Excellent Youth Team Program(2412023YQ001);the Finance Special Project on Medical and Health Talents of the Finance Department of Jilin Province(JLSWSRCZX2023-52);WBE Liver Fibrosis Foundation(2020009).

摘　　要：Alzheimer's disease(AD)is a neurodegenerative disease and a major threat to human health worldwide.The association between aluminum exposure and AD has been widely reported.Owing to the ubiquitous presence of aluminum in daily life;aluminum exposure can easily occur whenever and wherever possible.Thus;a rapid and sensitive reagent for detecting aluminum and assist in AD daily prevention for potential AD patient population is extremely needed.However;existing aluminum detection methods rely on precise instruments;which are impractical for household use.Herein;a series of aggregation-induced emission-based covalent-organic framework(AIE-COF)fluorescent probes has been designed with progressively tuned sizes and screened for aluminum detection.Among them;COF-N2 was found to have the highest response towards aluminum specifically;with a fluorescence intensity change of 19.14 times before and after chelation;which could determine the aluminum concentration by naked eye.Then;the molecular mechanism of COF-N2 fluorescence changes was explained and COF-N2 was used for both diagnose the aluminum distribution in various organs of APP/PS1 transgenic mice and quickly determine the aluminum content in daily necessities.The use of AIE-COF probes for aluminum detection provides a promising avenue for developing aluminum related AD clinical diagnosis and daily prevention tools.

关 键 词：Alzheimer's disease clinical detection daily prevention aluminum exposure aggregation-induced emission 

分 类 号：O657.3[理学—分析化学]