乳果糖联合聚乙二醇电解质散用于儿童纤维结肠镜肠道检查准备的评价  

Evaluation of lactulose and polyethylene glycol electrolyte solution for bowel preparation in pediatric colonoscopy

作　　者：蔡丽君 朱茂龙 舒蒙 远文瑛[1] Cai Li-jun;Zhu Mao-long;Shu Meng;Yuan Wen-ying(Department of Pediatric Gastroenterology,Hubei Maternal and Child Health Hospital,Wuhan 430000,China)

机构地区：[1]湖北省妇幼保健院儿童消化内科,武汉430000

出　　处：《中国药物应用与监测》2025年第2期297-300,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：目的探讨腹痛儿童进行纤维结肠镜前采取聚乙二醇电解质散联合乳果糖口服液进行肠道准备的价值。方法纳入湖北省妇幼保健院儿童消化内科收治的102例因腹痛进行纤维结肠镜检查的患儿(2020年1月至2024年10月),采取随机数字表法将患儿分为两组,各51例。对照组儿童肠道准备应用聚乙二醇电解质散,观察组儿童肠道准备则采取乳果糖口服液联合聚乙二醇电解质散。采取Boston肠道准备评分量表(BBPS)评估两组患儿肠道清洁质量,比较两组儿童纤维结肠镜检查时间(进镜时间与退镜时间、总时间)及肠道准备耐受度情况、结肠病变检出率、检查不良反应率。结果观察组儿童BBPS总分为(8.44±0.14)分,高于对照组的(7.78±0.15)分(t=22.971,P<0.05);观察组儿童进镜时间与退镜时间、总时间[分别为(7.23±0.26)min、(7.10±0.20)min、(16.02±0.23)min],均短于对照组[分别为(9.01±0.52)min、(8.96±0.36)min、(18.23±0.38)min](t=21.865、32.254、35.532,P<0.05);观察组肠道准备耐受度为98.04%(50/51),高于对照组的86.27%(44/51)(χ^(2)=4.883,P<0.05);结肠病变检出率方面,观察组为17.64%(9/51),对照组为15.68%(8/51),两组数据相当(χ^(2)=0.071,P>0.05);检查总不良反应率方面:观察组为1.96%(1/51)与对照组患儿3.92%(2/51)相当(χ^(2)=0.000,P>0.05)。结论儿童腹痛多应用纤维结肠镜检查,可较好诊断疾病,采取聚乙二醇电解质散联合乳果糖口服液进行肠道准备,可提升肠道清洁度,促进检查顺利进行,检查不良反应少,安全可靠。Objective To evaluate the efficacy of combining lactulose oral solution with polyethylene glycol electrolyte powder as a bowel preparation regimen prior to fiber colonoscopy in pediatric patients presenting with abdominal pain.Methods One hundred and two children who underwent fiberoptic colonoscopy for abdominal pain in Hubei Maternal and Child Health Hospital from January 2020 to October 2024 were divided into two groups of 51 each using a random number table method.The children in the control group received polyethylene glycol electrolyte powder for intestinal preparation,while those in the observation group received lactulose oral solution combined with polyethylene glycol electrolyte powder for intestinal preparation.The Boston bowel preparation scale(BBPS)was used to evaluate the quality of bowel hygiene in both groups.The time of fiberoptic colonoscopy examination(in and out time,total time),bowel preparation tolerance,colon lesion detection rate,and adverse reaction rate were compared between the two groups.Results The total BBPS score in the observation group was(8.44±0.14)points,which was higher than that in the control((7.78±0.15)points)(t=22.971,P<0.05).Observation group's admission time and exit time,total time were(7.23±0.26)min,(7.10±0.20)min,(16.02±0.23)min,respectively and it was shorter than that in the control((9.01±0.52)min,(8.96±0.36)min,(18.23±0.38)min,respectively)(t=21.865,32.254,35.532,P<0.05).The intestinal preparation tolerance of the observation group was 98.04%(50/51),higher than that of the control(86.27%(44/51))(χ^(2)=4.883,P<0.05).In terms of the detection rate of colon lesions,the observation group was 17.64%(9/51)and the control group was 15.68%(8/51),with comparable data between the two groups(χ^(2)=0.071,P>0.05).The total adverse reaction rate of children in observation group was 1.96%(1/51),which was similar to that in the control(3.92%(2/51)),showing no significant difference(χ^(2)=0.000,P>0.05).Conclusion Fiber colonoscopy is often used in children with abdominal

关 键 词：儿童腹痛 纤维结肠镜检查 聚乙二醇电解质散 乳果糖口服液 肠道清洁质量 纤维结肠镜检查时间 肠道准备耐受度 

分 类 号：R725.7[医药卫生—儿科]