复方倍他米松联合准分子激光治疗非节段型白癜风的疗效及不良反应  

Efficacy and adverse reactions of compound betamethasone combined with excimer laser therapy in patients with non-segmental vitiligo

作　　者：吕慧青 于晓倩 秦绪艳 路晓琳[1] Lyv Hui-qing;Yu Xiao-qian;Qin Xu-yan;Lu Xiao-lin(Department of Dermatology,Qingdao Hiser Hospital Affiliated to Qingdao University(Qingdao Hospital of Traditional Chinese Medicine),Qingdao 266033,China)

机构地区：[1]青岛大学附属青岛市海慈医院(青岛市中医医院)皮肤科,青岛266033

出　　处：《中国药物应用与监测》2025年第2期315-318,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：目的观察复方倍他米松联合308 nm准分子激光疗法对非节段型白癜风的临床疗效及不良反应观察。方法纳入2024年1月至2024年4月青岛大学附属青岛市海慈医院收治的64例稳定期非节段型白癜风患者,采用随机数表法分为研究组和对照组,各32例。两组均采用308 nm准分子激光疗法,每周治疗3次,连续治疗12周,研究组加用复方倍他米松肌内注射治疗,每3周注射1次,共注射4次。比较两组患者临床疗效、白癜风面积评分指数、皮损面积改善情况、皮损色素积分、细胞间黏附分子1、肿瘤坏死因子α及不良反应发生情况。结果研究组治疗有效率为90.63%(29/32),高于对照组的68.75%(22/32)(χ^(2)=4.730,P<0.05);治疗后,两组白癜风面积评分指数下降,且研究组[(1.29±0.34)分]低于对照组[(1.72±0.45)分](t=4.313,P<0.05);两组皮损面积均缩小,且研究组[(17.26±2.31)cm^(2)]低于对照组[(21.83±2.42)cm^(2)],两组皮损色素积分均升高,研究组[(2.05±0.16)分]高于对照组[(1.73±0.14)分](t=7.727,8.514,P<0.05);两组细胞间黏附分子1、肿瘤坏死因子α水平均降低,且研究组[(514.26±70.34)pg·L^(-1)、(9.15±1.56)pg·mL^(-1)]低于对照组[(552.82±72.41)pg·L^(-1)、(10.73±2.14)pg·mL^(-1)](t=2.329,3.375,P<0.05);研究组不良反应发生率为9.38%(3/32),低于对照组的15.63%(5/32),差异无统计学意义(χ^(2)=0.143,P>0.05)。结论复方倍他米松联合308 nm准分子激光疗法对非节段型白癜风的临床疗效较好,其能在保证安全性的基础上缩小白癜风皮损面积、改善皮损颜色、降低炎症因子水平。Objective To observe the clinical efficacy and adverse effects of compound betamethasone combined with 308 nm excimer laser therapy in treatment of non-segmental vitiligo.Methods A total of 64 patients with stable non-segmental vitiligo admitted to Qingdao Hiser Hospital from January 2024 to April 2024 were included in this study and divided into two groups using the random number table method,with 32 in each groups.All the patients in both groups were treated with 308 nm excimer laser therapy three times a week for 12 weeks,and those in the research group were additionally treated with compound betamethasone muscle injection once every 3 weeks for 4 injections.The clinical efficacy,vitiligo area scoring index(VASI),skin lesion area improvement,skin lesion pigment score,intercellular cell adhesion molecule 1(ICAM-1),tumor necrosis factorα(TNF-α)and the occurrence of adverse reactions were compared between the two groups.Results The effective rate in the research group was 90.63%(29/32),higher than 68.75%(22/32)in the control group(χ^(2)=4.730,P<0.05).After treatment,the VASI scores of both groups decreased,and the score of the research group((1.29±0.34)points)was lower than the control group((1.72±0.45)points)(t=4.313,P<0.05).The skin lesion areas of both groups were reduced,and it was lower in the research group((17.26±2.31)cm^(2))than in the control group((21.83±2.42)cm^(2))(t=7.727,P<0.05).The skin lesion pigment scores of both groups increased,and they were higher in the research group((2.05±0.16)points)than in the control group((1.73±0.14)points)(t=8.514,P<0.05).The levels of ICAM-1 and TNF-αin both groups were reduced,and they were lower in the research group((514.26±70.34)pg·L^(-1),(9.15±1.56)pg·mL^(-1))than in the control group((552.82±72.41)pg·L^(-1),(10.73±2.14)pg·mL^(-1))(t=2.329,3.375,P<0.05).The adverse reaction rate was 9.38%(3/32)in research group,which was lower than that of 15.63%(5/32)in the control group(χ^(2)=0.143,P>0.05).Conclusion Compound betamethasone combined with 308

关 键 词：复方倍他米松 激光疗法 非节段型白癜风 疗效 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]