玉屏风颗粒联合乙酰半胱氨酸对支原体肺炎患儿疗效及T淋巴细胞的影响  

Efficacy of Yupingfeng granule combined with acetylcysteine in children with mycoplasma neumoniae pneumonia and its impact on T lymphocytes

作　　者：冯慧玲[1] 王凯悦 宋建刚[1] 薛峥峰[1] Feng Hui-ling;Wang Kai-yue;Song Jian-gang;Xue Zheng-feng(Department of Pediatrics,Yan’an University Affiliated Hospital,Yan’an 716000,China)

机构地区：[1]延安大学附属医院儿科,延安716000

出　　处：《中国药物应用与监测》2025年第2期352-355,共4页Chinese Journal of Drug Application and Monitoring

基　　金：延安市科技计划项目(2022SLSFGG-026);延安大学附属医院科学技术研究发展计划项目(2022PT-10)。

摘　　要：目的探讨玉屏风颗粒联合乙酰半胱氨酸对支原体肺炎患儿的疗效及T淋巴细胞亚群的影响。方法选取2021年1月至2023年1月于延安大学附属医院就诊102例支原体肺炎患儿进行回顾性分析,根据治疗方法将患者分为对照组(乙酰半胱氨酸治疗)51例和试验组(乙酰半胱氨酸联合玉屏风颗粒治疗)51例。比较两组患儿临床疗效、症状消退时间、T淋巴细胞亚群变化及不良反应。结果试验组治疗后总有效率为96.08%(49/51)高于对照组的82.35%(42/51)(χ^(2)=4.993,P=0.025)。试验组患儿咳嗽、发热、喘息、啰音消退时间[分别为(5.35±0.89)d、(3.23±0.65)d、(2.67±0.58)d、(5.74±0.78)d]均短于对照组[分别为(6.12±1.32)d、(4.01±0.96)d、(3.54±0.84)d、、(6.45±1.12)d](t=3.454、4.805、6.087、3.715,均P<0.001)。试验组和对照组T淋巴细胞亚群CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平[分别为(65.87±7.23)%、(36.87±7.23)%、(1.47±0.42)、(61.23±6.18)%、(31.23±6.12)%、(1.26±0.25)]均高于治疗前[分别为(54.46±5.59)%、(26.45±5.59)%、(0.95±0.24)、(54.14±5.37)%、(26.14±5.37)%、(0.93±0.21)],且试验组高于对照组(t=3.484、4.252、3.068,均P<0.05)。两组不良反应总发生率分别为9.80%(5/51)、5.88%(3/51),差异无统计学意义(χ^(2)=0.136,P=0.713)。结论玉屏风颗粒联合乙酰半胱氨酸治疗支原体肺炎患儿疗效良好,能够更快缓解症状,改善T淋巴细胞亚群分布,且安全性良好。Objective To investigate the efficacy of Yupingfeng granule combined with acetylcysteine in treatment of mycoplasma pneumoniae pneumoniae(MPP)and its effect on T-lymphocyte subpopulations in children with MPP.Methods A total of 102 children with MPP admitted to Yan’an University Affiliated Hospital from January 2021 to January 2023 were selected for retrospective analysis and divided into the control group(n=51)and the experimental group(n=51)according to the treatment method.Children of the control group were treated with acetylcysteine and those of the experimental group were treated with acetylcysteine combined with Yupingfeng granules.Comparison of clinical efficacy,symptom improvement time,T-lymphocyte subpopulation changes and the incidence of adverse effects was performed between the two groups.Results The overall effective rate after treatment was 96.08%(49/51)in the experimental group and 82.35%(42/51)in the control(χ^(2)=4.993,P=0.025).The time for cough,fever,wheezing,and rales to subside in children in the experimental group((5.35±0.89)d,(3.23±0.65)d,(2.67±0.58)d,and(5.74±0.78)d)were all shorter than that in the control group((6.12±1.32)d,(4.01±0.96)d,(3.54±0.84)d,and(6.45±1.12)d)(t=3.454,4.805,6.087,3.715,all P<0.001).The CD3^(+),CD4^(+),CD4^(+)/CD8^(+)levels of T-lymphocyte subpopulations((65.87±7.23)%,(36.87±7.23)%,(1.47±0.42),(61.23±6.18)%,(31.23±6.12)%,and(1.26±0.25))were higher than that before the treatment in the experimental group and the control((54.46±5.59)%,(26.45±5.59)%,(0.95±0.24),(54.14±5.37)%,(26.14±5.37)%,(0.93±0.21)),and they were higher in the experimental group than in the control(t=3.484,4.252,3.068,all P<0.05).The total incidence of adverse reactions in the two groups was 9.80%(5/51)and 5.88%(3/51),respectively,and the difference was not statistically significant(χ^(2)=0.136,P=0.713).Conclusion The efficacy of Yupingfeng granules combined with acetylcysteine in the treatment of children with MPP is remarkable because it can alleviate the symptoms and impro

关 键 词：玉屏风颗粒 乙酰半胱氨酸 肺炎支原体肺炎 T淋巴细胞亚群 临床疗效 

分 类 号：R725.6[医药卫生—儿科]