蒙药额日敦-乌日勒对老年高血压患者血栓前状态及生活质量的影响  

Effect of Mongolian medicine Eridun Wurile on prothrombotic state and quality of life in elderly patients with hypertension

作　　者：那仁满都拉 斯琴 杨敖民 Narenmandula;Siqin;Yang Aomin(Department of Mongolian Medicine,People′s Hospital of Inner Mongolia Autonomous Region,Hohhot 010017,China;Second Department of Cardiology,Inner Mongolia International Mongolian Medical Hospital,Hohhot 010000,China;Inner Mongolia Medical University,Hohhot 010107,China)

机构地区：[1]内蒙古自治区人民医院蒙医科,呼和浩特010017 [2]内蒙古自治区国际蒙医医院心脏病二科,呼和浩特010000 [3]内蒙古医科大学,呼和浩特010107

出　　处：《中国医药》2025年第4期591-596,共6页China Medicine

基　　金：内蒙古自治区卫生健康科技计划(202201027);内蒙古自治区自然科学基金(2022MS08066);内蒙古自治区人民医院博士科研启动资金(2024BS01)。

摘　　要：目的探讨蒙药额日敦-乌日勒对老年高血压患者血栓前状态(PTS)及生活质量的影响。方法选取2023年1月至2024年2月就诊于内蒙古自治区人民医院蒙医科门诊及住院部的老年高血压患者60例,按随机数字表法分为对照组和观察组,各30例。对照组给予苯磺酸氨氯地平片治疗,观察组在对照组基础上加服蒙药额日敦-乌日勒治疗,2组疗程均为8周。观察2组患者治疗前后PTS分子标志物(凝血四项、D-二聚体)水平,生活质量量表评分以及血压、安全性指标等变化情况。结果60例患者中,观察组脱落1例,对照组失访1例,完成试验58例,脱失率3.3%(2/60)。观察组治疗前后凝血四项、D-二聚体比较,差异均有统计学意义(均P<0.05)。治疗后观察组纤维蛋白原(FIB)、D-二聚体差值均大于对照组[1.46(1.23,1.85)g/L比0.06(0.02,0.14)g/L、0.16(0.13,0.22)mg/L比0.03(0.02,0.04)mg/L](均P<0.05)。2组组内治疗前后收缩压、舒张压比较,差异均有统计学意义(均P<0.05)。观察组治疗前后生活质量量表各维度评分比较,差异均有统计学意义(均P<0.05)。2组生理症状、工作状态、人际关系敏感评分治疗前后差值比较,差异均有统计学意义(均P<0.05)。2组不良反应发生率比较,差异无统计学意义(P=0.313)。结论蒙药额日敦-乌日勒联合苯磺酸氨氯地平片对老年高血压患者PTS分子标志物及生活质量具有一定的改善作用,其中,对FIB、D-二聚体、生理症状、工作状态、人际关系敏感状态等指标的改善作用明显优于苯磺酸氨氯地平单药治疗。Objective To investigate the effect of Mongolian medicine Eridun Wurile on prothrombotic state(PTS)and quality of life in elderly patients with hypertension.Methods From January 2023 to February 2024,60 elderly patients with hypertension were selected from the outpatient and inpatient Department of Mongolian Medicine,People′s Hospital of Inner Mongolia Autonomous Region.According to the random number table method,they were divided into control group and observation group,with 30 cases in each group.The control group was treated with amlodipine besylate tablets,and the observation group was treated with Mongolian medicine Eridun Wurile on the basis of the control group.Both groups were treated for 8 weeks.The levels of PTS molecular markers(four items of blood coagulation,D-dimer),quality of life scale scores,blood pressure and safety indicators were observed before and after treatment in the two groups.Results Among the 60 patients,1 case dropped out of the observation group,1 case was lost to follow-up in the control group,and 58 cases completed the trial,with a dropout rate of 3.3%(2/60).There were statistically significant differences in four items of coagulation and D-dimer before and after treatment in the observation group(all P<0.05).After treatment,the differences of fibrinogen and D-dimer in the observation group were greater than those in the control group[1.46(1.23,1.85)g/L vs 0.06(0.02,0.14)g/L,0.16(0.13,0.22)mg/L vs 0.03(0.02,0.04)mg/L](both P<0.05).There were statistically significant differences in systolic blood pressure and diastolic blood pressure in the two groups between before and after treatment(all P<0.05).There were statistically significant differences in the scores of each dimension of the quality of life scale before and after treatment in the observation group(all P<0.05).There were statistically significant differences in the scores difference before and after treatment of physiological symptoms,working status and interpersonal sensitivity between the two groups(all P<0.05).There wa

关 键 词：高血压 蒙药额日敦-乌日勒 血栓前状态 生活质量 

分 类 号：R544.1[医药卫生—心血管疾病]