用于人工心脏瓣膜的硅氧烷改性聚氨酯研制  

Study on Silicone Modified Polyurethane for Artificial Heart Valves

作　　者：王奇 曾瑜 陈珊 尹亚飞 蒋涛[1] 郝同辉[1] WANG Qi;ZENG Yu;CHEN Shan;YIN Ya-fei;JIANG Tao;HAO Tong-hui(School of Materials Science and Engineering,Hubei University,Wuhan 430062)

机构地区：[1]湖北大学材料科学与工程学院,武汉430062

出　　处：《胶体与聚合物》2025年第1期10-12,共3页Chinese Journal of Colloid & Polymer

摘　　要：以聚四氢呋喃醚二醇(PTMG)、异佛尔酮二异氰酸酯(IPDI)、4,4'-亚甲基双(3-氯-2,6-二乙基苯胺)(M-CDEA)为基础原料,通过添加羟烃基双封端聚二甲基硅氧烷(PDMS)来改善聚氨酯产品的生物性能,得到的产品(Si PU)有望用于人工心脏瓣膜领域。本实验采用多种仪器,对Si PU的结构和性能进行了表征。结果表明:Si PU在PDMS的添加量为总质量的15%时,Si PU拉伸应力达到了29 MPa以上;其细胞毒性也为阴性,为植入人体用于心脏瓣膜材料开发提供了有利条件。In this study,polyurethane products(SiPU) with enhanced biocompatibility were developed using polytetramethylene ether glycol(PTMG),isophorone diisocyanate(IPDI),and 4,4'-methylenebis(3-chloro-2,6-diethyl-aniline)(M-CDEA) as base materials,with the addition of hydroxyl-terminated polydimethylsiloxane(PDMS).Various instruments were employed to characterize the structure and properties of SiPU.The results indicate that when PDMS constitutes 15% of the total mass,the tensile stress of SiPU exceeds 29 MPa.Additionally,the material exhibits negative cytotoxicity,making it a promising candidate for use in artificial heart valves.These findings provide favorable conditions for the development of cardiac valve materials suitable for human implantation.

关 键 词：聚氨酯 硅氧烷 细胞毒性 

分 类 号：TQ323.8[化学工程—合成树脂塑料工业]