苦参碱及衍生物的抗炎作用及其机制研究进展  

Research progress on anti-inflammatory effect and mechanism of matrine andits derivatives

作　　者：陶宫佳 陈林林 宋泽成 刘梦肖 王彦 TAO Gongjia;CHEN Linlin;SONG Zecheng;LIU Mengxiao;WANG Yan(School of Pharmacy,China Medical University,Shenyang 110122,China;Department of Anesthesiology,School of Pharmacy,Naval Medical University,Shanghai 200433,China;Center for Drug Discovery and Development,School of Pharmacy,Naval Medical University,Shanghai 200433,China;School of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China)

机构地区：[1]中国医科大学药学院,辽宁沈阳110122 [2]海军军医大学麻醉系,上海200433 [3]海军军医大学药学系军特药研究中心,上海200433 [4]福建中医药大学药学院,福建福州350122

出　　处：《药学实践与服务》2025年第4期163-168,194,共7页Journal of Pharmaceutical Practice and Service

基　　金：国家自然科学基金(81772124);上海市“科技创新行动计划”生物医药科技支撑专项(20S11902900)。

摘　　要：苦参碱是从中药植物苦参中分离提取的一种生物碱化合物,具有抗肿瘤、抗炎和抗病毒等作用,由于体内活性低、疗效时间短、毒副作用大等因素,其临床应用受到限制。为解决这一问题,药物专家对苦参碱的结构进行修饰获得其衍生物,以改善其缺点。目前,对苦参碱及衍生物抗肿瘤的研究比较多,在炎症性相关疾病中的研究还有待进一步加强。该文综述了苦参碱及衍生物在改善炎症性疾病中的作用及机制的研究进展,为苦参碱类药物研发提供线索。Matrine is an alkaloid compound isolated and extracted from the traditional Chinese medicinal plant Sophora flavescens,which has anti-tumor,anti-inflammatory,and anti-viral effects.However,its clinical application has been limited due to its low in vivo activity,short duration of efficacy,and significant toxic side effects.In response to this challenge,pharmaceutical experts modified the structure of Matrine to obtain derivatives that addressed its limitations.Currently,research on the anti-tumor effects of Matrine and its derivatives is more prevalent,while research in inflammatory-related diseases still needs further strengthening.The progress on the role and mechanism of Matrine and its derivatives in inflammatory diseases were summarized in this paper,which offered valuable insights for the development of therapeutic agents based on Matrine.

关 键 词：苦参碱 衍生物 抗炎作用 信号通路 

分 类 号：R285[医药卫生—中药学]