胎盘微血流联合血清Cys C对晚发型子痫前期的预测价值  

Prediction of Placental Microflow Combined with Serum Cystatin C in Late-Onset Preeclampsia

作　　者：王雯雯 唐琳 李凡[1] 朱桐 秦曼 陈玲[1] WANG Wenwen;TANG Lin;LI Fan;ZHU Tong;QIN Man;CHEN Ling(Department of Ultrasonography,the First Affiliated Hospital,School of Medicine,Shihezi University,Shihezi 832000,China)

机构地区：[1]石河子大学第一附属医院超声医学科,新疆石河子832000

出　　处：《中国医学影像学杂志》2025年第3期304-309,共6页Chinese Journal of Medical Imaging

基　　金：石河子大学医学院第一附属医院重点基金项目(DZ201902);兵团指导性项目(2023ZD005)。

摘　　要：目的探讨胎盘微血流联合血清胱抑素C(Cys C)预测发生晚发型子痫前期(LOP)的价值。资料与方法前瞻性纳入2021年10月—2022年10月在石河子大学第一附属医院接受产前超声检查并分娩的单胎妊娠孕妇188例,中孕期使用三维能量多普勒超声检测孕妇胎盘微血流指数,包括血管化指数、血流指数、血管化-血流指数(VFI),同时检测孕妇血清Cys C水平。将孕妇妊娠结局分为LOP组和正常组(NLOP组),分析胎盘微血流联合血清Cys C对LOP的预测价值。结果LOP组胎盘血管化指数、VFI均低于NLOP组(29.77±11.97比44.44±9.86,9.23±3.51比15.05±4.38),血清Cys C高于NLOP组[(1.13±0.17)mg/L比(0.84±0.18)mg/L],差异均有统计学意义(t=-3.616、-4.790、4.682,P均<0.05)。胎盘VFI联合血清Cys C预测LOP的曲线下面积为0.899,预测价值最高。结论胎盘VFI联合血清Cys C检测可提高LOP的预测效能,且优于各单项指标。Purpose To investigate the predictive value of placental microflow combined with serum cystatin C(Cys C)for late-onset preeclampsia(LOP).Materials and Methods This was a prospective study including 188 singleton pregnant women who underwent prenatal ultrasound examination and delivered in the First Affiliated Hospital,School of Medicine,Shihezi University from October 2021 to October 2022.The placental microvascular indexes,including vascularization index,flow index and vascularization-flow index(VFI),were detected by three-dimensional power Doppler ultrasound in the second trimester,and the serum Cys C level was detected.The pregnancy outcome of the pregnant women was divided into LOP group and normal group(NLOP group),and the predictive value of placental microflow combined with serum Cys C for LOP was analyzed.Results Placental vascularization index and VFI of the LOP group were lower than those of the NLOP group(29.77±11.97 vs.44.44±9.86,9.23±3.51 vs.15.05±4.38).However,serum Cys C in the LOP group was higher than that in the NLOP group[(1.13±0.17)mg/L vs.(0.84±0.18)mg/L],and the differences were statistically significant(t=-3.616,-4.790,4.682,all P<0.05).The area under the curve of placental VFI combined with serum Cys C for predicting LOP was 0.899,which had the highest predictive value.Conclusion Placental VFI combined with serum Cys C detection can help to improve the prediction efficiency of LOP,and it is better than each single item.

关 键 词：晚发型子痫前期 血管化指数 血流指数 血管化-血流指数 血清胱抑素C 超声检查 预测 

分 类 号：R714.244[医药卫生—妇产科学] R445.1[医药卫生—临床医学]