T2 mapping与3D-WATSc序列定量测量膝关节软骨体积的一致性  

Consistency of T2 Mapping and 3D-WATSc Sequences in Quantitative Measurement of Knee Cartilage Volume

作　　者：吴明杰 许亚飞 傅孙亚 张玉琴 徐凌斌 WU Mingjie;XU Yafei;FU Sunya;ZHANG Yuqin;XU Lingbin(Department of Nuclear Medicine,the Affiliated Lihuili Hospital of Ningbo University,Ningbo 315040,China;不详)

机构地区：[1]宁波大学附属李惠利医院影像科,浙江宁波315040 [2]宁波大学附属李惠利医院核医学科,浙江宁波315040

出　　处：《中国医学影像学杂志》2025年第3期320-325,共6页Chinese Journal of Medical Imaging

基　　金：浙江省医药卫生科技项目(2019KY610)。

摘　　要：目的探索T2 mapping与三维选择性水激发(3D-WATSc)序列测量膝关节软骨体积的一致性。资料与方法2022年5—12月宁波大学附属李惠利医院招募30名健康志愿者,行左膝关节3D-WATSc、T2mapping序列扫描。随机抽取20名受试者的T2 mapping序列,分析8组不同TE(13、26、39、52、65、78、91、104 ms)的原始图像,由2名观察者对原始图像质量进行评分,使用Kappa检验观察评分一致性,Welch方差分析和Games-Howell text事后检验得出最佳图像质量的TE。基于T2 mapping和3D-WATSc序列对30名受试者股骨髁、胫骨平台和髌骨后缘软骨体积进行半自动分割测量,使用组内相关系数(ICC)、BlandAltman检验T2 mapping序列下2名观察者间及两种序列测得软骨体积的一致性。结果2名观察者评分除TE 104 ms一致性较差(Kappa=0.318)、TE 78 ms差异无统计学意义(P=0.052)外,其余一致性均为中等(Kappa>0.40,P<0.05),进一步分析TE 26 ms软骨显示质量评分最佳(均值2.90)。将TE 26 ms与其余7组评分进行Games-Howell text两两比较,除与TE 13 ms(均值2.55)、TE 39 ms(均值2.62)两组评分差异无统计学意义(P>0.05)外,TE 26 ms与其余TE组评分差异均有统计学意义(P均<0.05)。在T2 mapping(TR 2000 ms、TE 26 ms)序列上,2名观察者分割得到各部分软骨体积的ICC均>0.6,P<0.05,以股骨髁软骨体积的一致性最好(ICC=0.877,P<0.01)。两种序列测得的各部分软骨体积一致性均较好(ICC均>0.75,P均<0.01),以胫骨平台软骨体积的一致性最好(ICC=0.857,P<0.01)。结论T2 mapping原始图像(TR 2000 ms、TE 26 ms)可清晰显示膝关节软骨形态,T2 mapping与3D-WATSc序列定量膝关节软骨体积的一致性较好,T2 mapping单一序列可为膝关节软骨形态及功能的一站式定量分析提供可信的扫描方案。Purpose To explore the consistency between T2 mapping and three-dimensional water-selective cartilage(3D-WATSc)sequence measurement of knee cartilage volume.Materials and Methods A total of 30 healthy volunteers were recruited and underwent 3D-WATSc and T2 mapping sequence scans of the left knee joint in the Affiliated Lihuili Hospital of Ningbo University from May to December 2022.A total of 20 subjects’T2 mapping sequences were randomly selected and eight groups of raw images with different TE(13,26,39,52,65,78,91,104 ms)were analyzed.The quality of the raw images was rated by two observers,and the consistency of two observers’scores were subjected by Kappa test.The TE value with the best image quality was determined via Welch analysis of variance and Games-Howell text post hoc test.Based on T2 mapping and 3D-WATSc sequences,semi-automatic segmentation measurements were performed on the cartilage volume of femoral condyle,tibial plateau and patellar posterior margin in 30 subjects.Intra group correlation coefficient(ICC)and Bland-Altman plot were used to test the consistency of cartilage volume between two observers under T2 mapping sequence,as well as between T2 mapping and 3D-WATSc sequences.Results The consistency of the scores of the two observers was moderate except for poor consistency at TE 104 ms(Kappa=0.318)and no statistical difference at TE 78 ms(P=0.052),with Kappa values greater than 0.40 and P<0.05,further analysis showed that the cartilage display quality score was optimal at TE 26 ms(M=2.90).Comparing TE 26 ms with the scores of the other seven groups in Games Howell text,except for TE 26 ms and TE 13 ms(M=2.55),TE 26 ms and TE 39 ms(M=2.62),which had no statistically significant difference in scores(P>0.05),there were significant differences in scores between TE 26 ms and the other TE groups(all P<0.05).On the T2 mapping(TR 2000 ms,TE 26 ms)sequence,the ICC values of the cartilage volumes of each part segmented by two observers were all greater than 0.6,P<0.05,with the consistency of femora

关 键 词：磁共振成像 T2 mapping 三维选择性水激发序列 膝关节 软骨 体积 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.72[医药卫生—诊断学]