Rational construction of enzyme-like stereoselective magnetic chiral nanozymes  

作　　者：Xuan Chen Shenli Wang Xiaoxiao Zhang Stefanos Mourdikoudis Chengxiao Song Leung Siu Lun Juan Xie Wing-leung Wong Jorge Perez-Juste Isabel Pastoriza-Santos Kwok-Yin Wong Guangchao Zheng 

机构地区：[1]Colloidal Physics Group,Key Laboratory of Materials Physics,Ministry of Education,School of Physics and Laboratory of Zhongyuan Light,Zhengzhou University,Zhengzhou 450001,China [2]Institute of Quantum Materials and Physics,Henan Academy of Sciences,Zhengzhou 450046,China [3]College of Food Science and Technology,Henan University of Technology,Zhengzhou 450001,China [4]State Key Laboratory of Chemical Biology and Drug Discovery,Department of Applied Biology and Chemical Technology,The Hong Kong Polytechnic University,Hong Kong 999077,China [5]CINBIO,Universidade de Vigo,Department of Physical Chemistry,Campus Universitario Lagoas Marcosende,36310 Vigo,Spain

出　　处：《Nano Research》2025年第4期316-324,共9页纳米研究(英文版)

基　　金：the National Natural Science Foundation of China(Nos.22271257,32202063,and 21902148);Natural Science Foundation of Henan(No.232300421096);the National Key R&D Program of China(No.2024YFE0105200);Start-up Research Fundation of Henan University of Technology(No.2021BS053);the Innovation and Technology Commission of Hong Kong,The Hong Kong Polytechnic University;the support from MICIU/AEI/10.13039/501100011033;ERDF/EU(No.PID2022-138724NB-I00);the Xunta de Galicia/ERDF(No.GRC ED431C 2020/09).

摘　　要：Recent studies support that magnetic chiral nanozymes,integrating the features of chirality,magnetism,and enzyme-like catalysis,provide new insights into the synthetic methodologies and applications of chiral nanozymes.In this study,we present the design of novel magnetic chiral cobalt superstructures(CoSSs)synthesized by the regulation of complex formation kinetics of Co3+with chiral ligands(L-or D-tartaric acid)under varying metal-to-ligand molar ratios and solvent polarity.This approach yielded a series of CoSSs with varying symmetry from high to low.The chiral CoSSs exhibited chirality-dependent peroxidase(POD)-like activity,demonstrating a high affinity of L-CoSSs towards substrates,with a chiral selective factor of approximately 1.37.In addition,the magneto-optical effects of the chiral CoSSs significantly enhanced their chiroptical performance from ultraviolet-visible(UV-vis)to near-infrared region.Under a magnetic field,the affinity of chiral CoSSs for substrates increases,while the chiral selective factor was modified to 0.76.This research on magnetic chiral CoSSs nanozymes opens promising new avenues for the application of artificial enzymes in fields,such as antibacterial technology,drug delivery,and biocatalysis.

关 键 词：chiral cobalt superstructures chirality origin solvent effect magnetic circular dichroism enzyme-like stereoselectivity 

分 类 号：O641[理学—物理化学]