光驱动铜催化羧酸及其衍生物脱羧偶联反应的研究进展  

Research Process on Photoinduced Copper-Catalyzed Decarboxylative Coupling Reactions of Carboxylic Acids and Their Derivatives

作　　者：刘艳红 张冬菊[3] Yanhong Liu;Dongju Zhang(Department of Radiology,the Second Affiliated Hospital of Shandong First Medical University,Taian 271000,China;School of Radiology,Shandong First Medical University and Shandong Academy of Medical Sciences,Taian 271016,China;School of Chemistry and Chemical Engineering,Shandong University,Jinan 250100,China)

机构地区：[1]山东第一医科大学第二附属医院放射科,泰安271000 [2]山东第一医科大学(山东省医学科学院)放射学院,泰安271016 [3]山东大学化学与化工学院,济南250100

出　　处：《化学进展》2025年第2期281-292,共12页Progress in Chemistry

基　　金：国家自然科学基金项目(Nos.22303045,22273051);山东省高等教育本科教学改革研究项目(No.Z2022169);山东大学教育教学改革研究项目(No.2024Z07)资助。

摘　　要：可见光驱动铜催化羧酸及其衍生物脱羧偶联反应是一种新型、高效且绿色的合成方法,可构建多种碳-碳和碳-杂原子键,用于合成具有各类高附加值化学品,因此成为现代合成化学领域的研究热点。近年来,国内外科研工作者在该领域开展了大量研究,取得了一系列创新性成果,被广泛应用于有机合成、材料科学和药物化学等领域。本文综述了可见光驱动铜催化羧酸及其衍生物脱羧偶联反应的实验和理论研究进展,重点介绍了几类典型的羧酸及其衍生物形成C—X(X=C、N、O、S)键的交叉偶联反应,并对其未来发展前景进行展望。The visible-light-driven copper-catalyzed decarboxylative coupling reaction of carboxylic acids and their derivatives is a novel,efficient,and green synthetic method.It allows the construction of various carbon-carbon and carbon-heteroatom bonds for the synthesis of a wide range of high-value-added chemicals,making it a hot topic in the field of modern synthetic chemistry.In recent years,researchers worldwide have conducted extensive studies in this area,achieving a series of innovative results that have been widely applied in organic synthesis,materials science,and medicinal chemistry.This paper reviews the latest experimental and theoretical advances in the visible-light-driven copper-catalyzed decarboxylative coupling reactions of carboxylic acids and their derivatives,with a focus on several typical cross-coupling reactions that form C-X(X=C,N,O,S)bonds.It also discusses the future development prospects of this catalytic method.

关 键 词：光催化 铜络合物 羧酸 脱羧 交叉偶联反应 

分 类 号：O621[理学—有机化学] O622.5[理学—化学] O643