2012—2022年河南省丙型肝炎流行特征及空间聚集性分析  

Epidemiological trends and spatial clustering analysis of hepatitis C in Henan Province from 2012 to 2022

作　　者：邱瑞杰 李洁[2] 马彦民[2] 聂玉刚[2] 周慧萍 李宁[2] 谢佳政 张国龙 刘洋[1,2] QIU Ruijie;LI Jie;MA Yanmin;NIE Yugang;ZHOU Huiping;LI Ning;XIE Jiazheng;ZHANG Guolong;LIU Yang(School of Public Health,Zhengzhou University,Zhengzhou 450001,China;Henan Provincial Center for Disease Control and Prevention)

机构地区：[1]郑州大学公共卫生学院,河南郑州450001 [2]河南省疾病预防控制中心

出　　处：《现代疾病预防控制》2025年第3期178-184,共7页MODERN DISEASE CONTROL AND PREVENTION

基　　金：河南省科技发展计划(232102310275);河南省医学科技攻关计划联合共建项目(LHGJ20210142,LHGJ20220159)。

摘　　要：目的分析2012—2022年河南省报告丙型肝炎(简称丙肝)病例的流行病学特征和趋势,为消除丙肝危害提供科学依据。方法根据中国疾病预防控制信息系统传染病报告信息管理系统中2012—2022年河南省报告丙肝病例数据,分析河南省丙肝的流行特征。使用Joinpoint 4.9.1.0软件进行时间趋势分析,使用Arcgis 10.2软件进行空间自相关分析。结果2012—2022年河南省累计报告丙肝279616例,年均发病率26.01/10万,丙肝报告病例数呈下降趋势(AAPC=-8.7%,P<0.001)。2012—2022年河南省各地市报告病例和各年龄段发病率均呈现下降趋势(P均<0.05)。男女性别比从2012的0.96∶1上升到2022年的1.10∶1。年龄主要集中在40~<80岁人群(83.31%),职业分布主要集中在农民(69.98%)、家务及待业(12.17%)和离退人员(7.71%)。全局空间自相关分析显示,河南省丙肝发病具有空间聚集性,局部空间自相关结果显示,高-高聚集区主要分布在郑州市、驻马店市、许昌市、南阳市和信阳市部分县区。结论2012—2022年河南省丙肝报告发病率较高,各地市和各年龄段的发病率整体呈下降趋势,男女性别比上升,40~<80岁人群、农民是丙肝感染的重点人群,聚集区域明显,应进一步加强对重点地区和人群的病例筛查及宣传和教育的力度。Objective To analyze the epidemiological characteristics and trends of reported hepatitis C cases in Henan Province,aiming to provide evidence for eliminating the hazard of hepatitis C.Methods Based on the data of hepatitis C in Henan Province collected by the Communicable Disease Reporting Information System,Chinese Disease Control and Prevention Information System from 2012 to 2022,the descriptive epidemiological methods were employed to analyze the epidemiological characteristics of hepatitis C in Henan Province.Joinpoint 4.9.1.0 software was employed to analyze and describe the epidemiological trends in hepatitis C.Arc GIS 10.2 software was used for spatial autocorrelation analysis.Results From 2012 to 2022,in Henan Province a total of 279616 cases of hepatitis C were reported,with an average annual incidence rate of 26.01 per100000,showing an overall downward trend over the years(AAPC=-8.7%,P<0.001).From 2012 to 2022,the incidence rates for all cities and age groups in Henan Province showed a decreasing trend(all P<0.05).The male-to-female ratio increased from 0.96:1 in 2012 to 1.10:1 in2022.The majority of the cases were 40-<80 years old(accounting for 83.31%).The main occupations of the cases were farmers(69.98%),followed by the housework or unemployment(12.17%),and retirement(7.71%).The global spatial autocorrelation analysis demonstrated that the incidence of hepatitis C presented an obvious spatial clustering distribution.Local spatial autocorrelation analysis showed that the high-high clustering areas were mainly in some counties and districts of Zhengzhou City,Zhumadian City,Xuchang City,Nanyang City and Xinyang City.Conclusions The reported incidence rate of hepatitis C was relatively high in Henan Province from 2012 to 2022.The incidence rates of hepatitis C for all cities and age groups in Henan Province showed an overall downward trend,and the male to female ratio increased.The persons aged 40-<80 years and farmers were the key groups of hepatitis C infection;there were obviously clustering areas.

关 键 词：丙型肝炎 流行病学特征 Joinpoint回归分析 时空分析 

分 类 号：R512.6[医药卫生—内科学] R181[医药卫生—临床医学]