多重益生菌对早产儿高胆红素血症的防治作用和对其神经发育的影响  

The preventive and therapeutic effects of multiple probiotics on hyperbilirubinemia and neurodevelopment in preterm infants

作　　者：王军[1] 唐晓康 张宇航 宋娟[1] 徐发林[1] 董慧芳[1] 夏磊[1] 曹洋洋 郭倩玉 WANG Jun;TANG Xiaokang;ZHANG Yuhang;SONG Juan;XU Falin;DONG Huifang;XIA Lei;CAO Yangyang;GUO Qianyu(Department of Pediatric,the Third Afiliated Hospital of Zhengzhou University/Henan Clinical Research Center for Pediatric Diseases,Zhengzhou,Henan 450052,China)

机构地区：[1]郑州大学第三附属医院儿科/河南省儿科疾病临床医学研究中心,河南郑州450052

出　　处：《现代疾病预防控制》2025年第3期230-234,共5页MODERN DISEASE CONTROL AND PREVENTION

摘　　要：目的探讨多重益生菌对早产儿高胆红素血症的防治作用及对其神经发育的影响,为早产儿高胆红素血症的临床治疗提供依据。方法选择于2022年2月1日至2023年2月1日在郑州大学第三附属医院新生儿科住院治疗的104例早产儿,按随机数字表法分成观察组和对照组各52例。对照组给予常规治疗,观察组在常规治疗的基础上,于生后第2天给予添加多重益生菌。监测指标主要包括生后第1、7、14 d的血清总胆红素(TBIL)和血清总胆红素/血浆白蛋白值(B/A值)、高胆红素血症发病率以及智能发育评定分值。结果治疗14 d后,观察组血清总胆红素水平低于对照组,分别为(120.02±5.99)、(145.92±6.26)μmol/L,差异有统计学意义(t=2.883,P<0.05)。观察组高胆红素血症发病率较对照组降低,分别为5.77%、19.23%,差异有统计学意义(t=4.227,P<0.001)。观察组纠正月龄6月时精神运动发育指数、智能发育指数分别为(89.06±9.02)、(91.59±6.04),均高于对照组(82.00±7.44)、(81.63±9.66),差异均具有统计学意义(t=2.443、4.576,P均<0.05)。结论早产儿出生后早期口服多重益生菌对新生儿高胆红素血症有防治作用,并且对早产儿神经发育有一定的促进作用。Objective To explore the preventive and therapeutic effects of multiple probiotics on hyperbilirubinemia and neurodevelopment in preterm infants,providing a basis for clinical treatment of hyperbilirubinemia in preterm infants.Methods A total of 104 preterm infants treated in the Neonatal Department,the Third Affiliated Hospital of Zhengzhou University from February 1,2022 to February 1,2023 were selected,and were divided into observation group and control group with 52 cases in each group using random number table method.The control group was given conventional treatment.Besides conventional treatment,the observation group was given multiple probiotics on the second day after birth.The monitoring indicators mainly included serum total bilirubin(TBIL),serum total bilirubin/plasma albumin(B/A),incidence rate of hyperbilirubinemia and intelligence development assessment score on the 1st,7th and 14th days after birth.Results After 14 days of treatment,TBIL level in the observation group was lower than that in the control group,which were(120.02±5.99)and(145.92±6.26)μmol/L,respectively,having a statistically significant difference(t=2.883,P<0.05).The incidence of hyperbilirubinemia in the observation group was lower than that in the control group,which were 5.77%and 19.23%,respectively,having a statistically significant difference(t=4.227,P<0.001).At a corrected age of 6 months,the mental motor developmental index and the intelligence developmental index in the observation group were(89.06±9.02)and(91.59±6.04),respectively,both higher than those in the control group,which were(82.00±7.44)and(81.63±9.66),respectively,having statistically significant differences(t=2.443 and 4.576,respectively;both P<0.05).Conclusions Early oral administration of multiple probiotics in preterm infants after birth has an effect on the prevention and treatment of neonatal hyperbilirubinemia,and has a certain promotion of neurodevelopment in preterm infants.

关 键 词：益生菌 早产儿 高胆红素血症 新生儿黄疸 神经发育 

分 类 号：R722.6[医药卫生—儿科]