事件相关电位N170在孤独症谱系障碍的临床应用前景  

Clinical prospects of the N170 event-related potential in autism spectrum disorder

作　　者：邓嘉瑞 王卓 钟祺 邵明健 陈卓铭[1] DENG Jia-rui;WANG Zhuo;ZHONG Qi;SHAO Ming-jian;CHEN Zhuo-ming(Department of Rehabilitation Medicine,the First Affiliat Hospital of Jinan University,Guangzhou 510630,Guangdong,China;不详)

机构地区：[1]暨南大学附属第一医院康复医学科,广东广州510630 [2]合肥市智能机器人研究院,安徽合肥230071

出　　处：《广东医学》2025年第3期339-343,共5页Guangdong Medical Journal

基　　金：广东省重点领域研发计划项目(2019B030335001);广州市重点研发计划资助(202103000027)。

摘　　要：孤独症谱系障碍(autism spectrum disorder,ASD)是一类发生于儿童早期的神经系统发育障碍性疾病,给家庭和社会带来巨大损失,诊断主要依赖行为量表,主观性高,需要较高配合度,因此寻找客观标记则显得极为重要。N170作为面孔诱发的事件相关电位负波成分,被认为是极有前景的客观标记,通过介绍N170与ASD,就N170在ASD诊断尤其早期诊断和临床评估等方面的前景进行了综述,并讨论了相关机制。Autism spectrum disorder(ASD)is a neurodevelopmental disorder that emerges in early childhood,imposing significant burdens on families and society.Currently,ASD diagnosis primarily depends on behavioral rating scales,which are highly subjective and require considerable cooperation from patients.Hence,the identification of objective biomarkers is crucial.The N170-an event-related potential component elicited by faces-is considered a highly promising objective marker.This review examines the relationship between the N170 and ASD,focusing on its potential applications in early diagnosis and clinical assessment.Additionally,the review discusses the underlying mechanisms associated with N170 in the context of ASD.

关 键 词：孤独症谱系障碍 N170 客观标记 倒立面孔效应 

分 类 号：R444[医药卫生—诊断学] R493[医药卫生—临床医学]