慢性心力衰竭并发心律失常患者血清sST2、CysC、hs-CRP/PAB水平变化及其诊断价值  

Changes and diagnostic value of serum sST2,CysC,and hs-CRP/PAB levels in patients with chronic heart failure complicated by arrhythmia

作　　者：吕晓翠 修天元 时秀文 王紫监[1] LU Xiaocui;XIU Tianyuan;SHI Xiuwen;WANG Zijian(Department of Cardiac Medicine,the Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075100,China)

机构地区：[1]河北北方学院附属第二医院心血管内三科,河北张家口075100

出　　处：《热带医学杂志》2025年第2期201-204,共4页Journal of Tropical Medicine

基　　金：河北省卫生健康委员会2024年计划项目(20241647);张家口市科学技术局2023年市级科技计划自筹经费项目(2322103D)。

摘　　要：目的分析慢性心力衰竭并发心律失常患者血清可溶性致癌抑制因子2(sST2)、胱抑素C(CysC)、超敏C反应蛋白/前清蛋白(hs-CRP/PAB)变化及其诊断价值,探究这些指标的临床应用价值。方法选取2022年1月-2023年6月河北北方学院附属第二医院收治的慢性心力衰竭患者105例,根据心律失常情况分为心律失常组(n=45)和非心律失常组(n=60)。比较两组血清sST2、CysC、hs-CRP/PAB水平及左室功能相关指标,利用Pearson相关性分析和受试者工作特征(ROC)曲线分别分析相关性和诊断价值。结果心律失常组血清sST2、CysC、hs-CRP/PAB水平高于非心律失常组,左室射血分数(LVEF)、二尖瓣口舒张期血流E峰/A峰(E/A)值低于非心律失常组,左室舒张末期内径(LVEDD)长于非心律失常组,差异均有统计学意义(t=5.930、5.327、4.364、13.772、8.072、7.070,P均<0.05)。慢性心力衰竭合并心律失常患者血清sST2、CysC、hs-CRP/PAB水平与LVEF、E/A成负相关(P<0.05);与LVEDD成正相关(P<0.05)。血清sST2、CysC、hs-CRP/PAB联合检测诊断的曲线下面积(AUC)为0.937,高于三者单独检测,差异有统计学意义(P<0.05)。结论sST2、CysC、hs-CRP/PAB在慢性心力衰竭合并心律失常患者中水平升高,三者表达水平与患者左室功能存在密切联系,且三者联合检测的诊断价值更高。Objective To analyze the changes in serum soluble suppression of tumorigenicity 2(sST2),cystatin C(CysC),and hypersensitivity C-reactive protein/prealbumin(hs-CRP/PAB)levels and their diagnostic value in patients with chronic heart failure complicated by arrhythmia.Methods A total of 105 patients with chronic heart failure admitted to the Second Affiliated Hospital of Hebei North University from January 2022 to June 2023 were selected and divided into an arrhythmia group(n=45)and a non-arrhythmia group(n=60)according to the arrhythmia status.The serum sST2,CysC,hs-CRP/PAB levels and left ventricular function-related indicators were compared between the two groups,and the Pearson correlation analysis and receiver operating characteristic(ROC)curve were used to analyze the correlation and diagnostic value,respectively.Results Serum sST2,CysC and hs-CRP/PAB levels were higher in the arrhythmia group than those in the nonarrhythmia group;left ventricular ejection fraction(LVEF),peak E/peak A(E/A)values of mitral orifice diastolic flow were lower than those in the non-arrhythmia group,and left ventricular end-diastolic internal diameter(LVEDD)were longer than those in the non-arrhythmia group,and the differences were statistically significant(t=5.930,5.327,4.364,13.772,8.072,7.070;all P<0.05).In the combined chronic heart failure arrhythmia patients,serum sST2,CysC,hs-CRP/PAB levels were negatively correlated with LVEF and E/A(P<0.05),and were positively correlated with LVEDD(P<0.05).The area under the curve(AUC)value for the combined diagnosis of serum sST2,CysC,hs-CRP/PAB was 0.937,which was higher than that of the three tests alone(P<0.05).Conclusions The levels of sST2,CysC,and hs-CRP/PAB were elevated in patients with chronic heart failure and arrhythmia.The expression levels of the three were closely related to the left ventricular function of the patients,and the combined detection of the three had a higher diagnostic value.

关 键 词：慢性心力衰竭 心律失常 可溶性致癌抑制因子2 胱抑素C 超敏C反应蛋白 前清蛋白 

分 类 号：R541.6[医药卫生—心血管疾病]