基于Joinpoint模型的2008-2023年百色市HIV/TB双重感染流行趋势分析  

Epidemiological trend analysis of HIV/TB co-infection in Baise city from 2008 to 2023 based on Joinpoint model

作　　者：何雨昕 陈坚 廖建英[1] 汤健闻 HE Yuxin;CHEN Jian;LIAO Jianying;TANG Jianwen(School of Public Health,Youjiang Medical University for Nationalities,Baise,Guangxi 533000,China;Baise Centre for Disease Control and Prevention,Baise,Guangxi 533000,China)

机构地区：[1]右江民族医学院公共卫生学院,广西百色533000 [2]百色市疾病预防控制中心,广西百色533000

出　　处：《热带医学杂志》2025年第2期263-267,共5页Journal of Tropical Medicine

基　　金：百色市科技计划项目(20203101,20222037,20233201)。

摘　　要：目的分析2008-2023年百色市人类免疫缺陷病毒(HIV)感染者合并结核病(TB)感染的流行趋势,为百色市HIV/TB双重感染防治工作提供科学依据。方法利用中国疾病预防控制信息系统中艾滋病和肺结核基本信息管理系统资料筛选出HIV/TB双重感染患者和其基本信息,计算不同年度HIV/TB双重感染比例,通过Joinpoint回归模型分析HIV/TB双重感染的趋势变化。结果2008-2023年百色市报告HIV/TB双重感染1057例,感染比例为9.04%。不同性别、婚姻状况、文化程度和感染途径的HIV/TB双重感染比例,差异均有统计学意义(χ^(2)=113.684、13.481、18.081、182.877,P均<0.05)。经Joinpoint回归模型分析结果显示HIV/TB双重感染比例整体呈下降趋势(AAPC=-10.08%,P<0.05)。男、女性双重感染比例趋势变化平行(P=0.454),两者整体均呈下降趋势(AAPC=-11.26%,P=0.002)。<50岁和≥50岁组双重感染比例趋势变化平行(P=0.622),两者整体均呈下降趋势(AAPC=-10.97%,P<0.001)。经性途径感染者和经注射吸毒感染者双重感染比例趋势变化不平行(P=0.045),两者以不同速度呈下降趋势(AAPC=-11.83%、-51.82%,P均<0.001)。结论百色市HIV/TB双重感染比例呈下降趋势,但男性和经注射吸毒感染的HIV/AIDS患者HIV/TB双重感染比例相对较高,应制定针对性HIV/TB双重感染防控干预措施。Objective To analyze the epidemiological trend of human immunodeficiency virus(HIV)-infected patients complicated with tuberculosis(TB)infection in Baise city from 2008 to 2023,so as to provide a scientific basis for the prevention and treatment of HIV/TB co-infection in Baise city.Methods The data of the basic information management system of AIDS and tuberculosis in the Chinese Disease Control and Prevention Information System were used to screen for the patients with HIV/TB co-infection,and the HIV/TB co-infection rate in different years was calculated,and the trend of HIV/TB co-infection was analyzed by Joinpoint regression model.Results From 2008 to 2023,1057 cases of HIV/TB coinfection were reported in Baise city,with an infection rate of 9.04%.The proportion of HIV/TB co-infections by gender,marital status,educational level and infection route were all statistically significant(χ^(2)=113.684,13.481,18.081,182.877;all P<0.05).The results of Joinpoint regression model analysis showed that the proportion of HIV/TB co-infection showed a downward trend as a whole(AAPC=-10.08%,P<0.05).The trend of the proportion of co-infection in men and women was parallel(P=0.454),and both showed a downward trend(AAPC=-11.26%,P=0.002).The trend of the proportion of coinfection in<50 years old group and≥50 years old group was parallel(P=0.622),and both of them showed a downward trend(AAPC=-10.97%,P<0.001).The trend of the proportion of co-infection between sexually transmitted infections and injecting drug users was not parallel(P=0.045),and both showed a downward trend at different rates(AAPC=-11.83%,-51.82%;both P<0.001).Conclusions The HIV/TB co-infection rate in Baise city was on a downward trend,but the HIV/TB co-infection rate in men and HIV/AIDS patients infected through injection drug use was relatively high.Targeted HIV/TB co-infection prevention and control intervention measures should be formulated.

关 键 词：人类免疫缺陷病毒 结核病 双重感染 流行趋势 Joinpoint回归分析 

分 类 号：R512.91[医药卫生—内科学]