会厌囊肿感染并发急性会厌炎呼吸道分泌物病原菌及血清NO、MMP-2、IL-8表达  

Pathogens isolated from respiratory tract secretions and expressions of serum NO,MMP-2 and IL-8 in epiglottic cyst infection patients complicated with acute epiglottitis

作　　者：黄应亮 张健 金开林 HUANG Yingliang;ZHANG Jian;JIN Kailin(The First People's Hospital of Linping District,Hangzhou,Zhejiang 31l100,China)

机构地区：[1]杭州市临平区第一人民医院耳鼻咽喉科,浙江杭州311100

出　　处：《中华医院感染学杂志》2025年第5期687-691,共5页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生健康基金资助项目(2024XY021)。

摘　　要：目的分析会厌囊肿感染并发急性会厌炎患者呼吸道分泌物病原菌分布及血清一氧化氮(NO)、基质金属蛋白酶2(MMP-2)、白细胞介素-8(IL-8)表达及临床意义。方法收集2019年1月-2023年6月杭州市临平区第一人民医院收治的98例会厌囊肿感染并发急性会厌炎患者临床资料,记录会厌部呼吸道分泌物病原菌分布情况;45例行保守治疗(非手术组),53例行支撑喉镜下电刀切除治疗(手术组),比较两组患者血清NO、MMP-2和IL-8水平变化、出院6个月后复发情况,使用受试者工作特征(ROC)曲线评估入院时血清NO、MMP-2和IL-8水平对非手术组6个月复发的预测价值。结果98例患者共检出61株病原菌,其中革兰阴性菌占比63.93%,革兰阳性菌占比36.07%。两组患者入院后血清NO、MMP-2和IL-8水平均低于入院时(P<0.05),且入院第7天均低于入院第3天(P<0.05);手术组入院第7天血清NO、MMP-2和IL-8均低于非手术组(P<0.05)。出院后6个月,手术组复发率低于非手术组(0.00%vs.13.33%,连续校正χ^(2)=5.387,P=0.020)。ROC曲线分析显示,入院时血清NO、MMP-2和IL-8对预测非手术组出院后6个月复发具有统计学意义(P<0.05)。结论相较于保守治疗,支撑喉镜下电刀切除治疗能降低会厌囊肿感染并发急性会厌炎的复发率,入院时血清NO、MMP-2和IL-8可辅助预测保守治疗的复发风险。OBJECTIVE To explore the distribution of pathogens isolated from respiratory tract secretions,observe the expressions of serum nitric oxide(NO),matrix metalloproteinase-2(MMP-2)and interleukin-8(IL-8)in the epiglottic cyst infection patients complicated with acute epiglottitis,and analyze the clinical significance.METHODS The clinical data were collected from 98 epiglottic cyst infection patients complicated with acute epiglottitis who were treated in the First People′s Hospital of Linping District from Jan.2019 to Jun.2023.The distribution of pathogens isolated from the respiratory tract secretions was recorded.Among the enrolled patients,45 patients who received conservative therapy were assigned as the non-surgery group,and 53 patients who underwent electrotome resection under self-retaining laryngoscope were assigned as the surgery group.The levels of serum NO,MMP-2 and IL-8 were compared between the two groups of patients,the recurrence rate was observed and compared after the discharge for 6 months.The values of serum NO,MMP-2 and IL-8 at the admission in prediction of recurrence of the non-surgery group 6 months after the surgery were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS Totally 61 strains of pathogens were isolated from the 98 patients,63.93%of which were gram-negative bacteria,and 36.07%were gram-positive bacteria.The levels of serum NO,MMP-2 and IL-8 of the two groups were lower after the discharge than at the admission(P<0.05),which were lower on the 7th day of admission than on the 3rd day of admission(P<0.05).The levels of serum NO,MMP-2 and IL-8 of the surgery group were lower than those of the non-surgery group on the 7th day of discharge(P<0.05).The recurrence rate of the surgery group was 0 after the discharge for 6 months,lower than 13.33%of the non-surgery group(0.00%vs.13.33%,continuity correctionχ^(2)=5.387,P=0.020).ROC curve analysis showed that the levels of serum NO,MMP-2 and IL-8 at the admission had statistical significance in prediction of recurre

关 键 词：会厌囊肿 感染 急性会厌炎 病原菌 一氧化氮 基质金属蛋白酶2 白细胞介素-8 复发 

分 类 号：R767.5[医药卫生—耳鼻咽喉科]