光解酶和藻蓝蛋白复合物在护肤品中的人体功效研究  

Study on the Human Efficacy of Photolyase and Phycocyanin in Skin Care Products

作　　者：王刚 王玲 廖知恒 张家威 赵晨媚 WANG Gang;WANG Ling;LIAO Zhiheng;ZHANG Jiawei;ZHAO Chenmei(Sichuan ASYA Wellness Management Co.,LTD.,Chengdu 610000,Sichuan,China)

机构地区：[1]四川爱莎健康管理有限公司,四川成都610000

出　　处：《中国美容医学》2025年第4期10-15,31,共7页Chinese Journal of Aesthetic Medicine

摘　　要：目的:评价含光解酶和藻蓝蛋白复合物的护肤品减少紫外线造成红斑和黑色素生成以及美白和抗衰的功效。方法:招募10名符合要求的志愿者通过紫外线灯照射手臂内侧皮肤试验,采用Antera3D CS多功能3D皮肤成像分析仪评价红斑和黑色素抑制率;另招募30名符合要求的志愿者作为研究对象进行人体临床试验,通过皮肤颜色测试探头Colorimeter CL400、Antera3D CS多功能3D皮肤成像分析仪、VISIA评价使用测试产品前后各项指标的变化;在使用配方1护肤精华液28 d后采用李克特5分制评分法调查志愿者对使用效果的满意度以及不良反应。结果:使用含光解酶和藻蓝蛋白复合物的护肤品对紫外照射后24 h皮肤红斑的抑制率达到42.31%、黑色素抑制率达到37.78%;人体临床试用14 d及28 d后,ITA°(个体皮肤类型角)值分别增加10.72%及12.98%、色素沉着评分分别下降15.27%及20.83%、皱纹体积分别减少26.40%及55.63%、皱纹最深值分别下降13.63%及32.51%;VISIA图像对比显示皮肤棕色斑明显淡化和减少;主观评价结果显示含光解酶和藻蓝蛋白复合物的护肤品具有均一肤色、减淡黄气、淡化色素沉着、提亮肤色的功效。结论:含光解酶和藻蓝蛋白复合物的护肤品可以减少紫外线造成的皮肤损伤及黑色素增加,具有美白、延缓肌肤老化的功效。Objective Conduct clinical efficacy tests on photolyase and phycocyanin skincare products to evaluate their effectiveness in reducing UV induced erythema and melanin production,whitening,and anti-aging effects.Methods Recruit 10 qualified volunteers to shine ultraviolet light on the inner skin of the arm test.Recruited 30 volunteers who meet the requirements as research subjects for human clinical trials,and evaluated the changes in various indicators,before and after using test products,through the skin color testing probe Colorimeter CL400,ANTERA 3D®,and VISIA®.After using Formula 1 skin care essence for 28 days,the volunteers'satisfaction and adverse reactions were investigated by using 5-point Likert scale.Results The results have showed that skincare products containing photolyase and phycocyanin has an inhibitory rate of 42.31%on skin erythema and 37.78%on melanin after 24 hours of ultraviolet radiation.After using skincare products containing photolyase and phycocyanin for 14 and 28 days,the ITA°(individual skin type angle)value increased by 10.72%and 12.98%,the pigmentation score decreased by 15.27%and 20.83%,the wrinkle volume decreased by 26.40%and 55.63%,and®the deepest wrinkle value decreased by 13.63%and 32.51%,respectively.The comparison of VISIA images shows that that skincare products containing photolyase and phycocyanin have the effects of unifying skin tone,reducing yellowing,reducing discoloration,and brightening skin tone.Conclusion The results indicate that skincare products containing photolyase and phycocyanin can reduce skin damage and melanin deposition caused by ultraviolet radiation,and have the effect of whitening and delaying skin aging.

关 键 词：光解酶 藻蓝蛋白 红斑 皮肤衰老 美白 黑色素 

分 类 号：TQ658[化学工程—精细化工]