黄芪多糖在治疗2型糖尿病及其并发症中的研究进展  

Research progress in Astragalus polysaccharide for type 2 diabetes mellitus and its complications

作　　者：李小龙 韩超 郭万慧 孙力康 张玥[3] LI Xiao-long;HAN Chao;GUO Wan-hui;SUN Li-kang;ZHANG Yue(Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301600;School of Integrative Traditional Chinese and Western Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301600;Center for Drug Safety Evaluation,Tianjin University of Traditional Chinese Medicine,Tianjin 301600)

机构地区：[1]天津中医药大学中医药研究院,天津301600 [2]天津中医药大学中西医结合学院,天津301600 [3]天津中医药大学药物安全评价中心,天津301600

出　　处：《中南药学》2025年第4期1066-1072,共7页Central South Pharmacy

基　　金：校企合作项目(No.TM01)。

摘　　要：2型糖尿病是一种以胰岛β细胞功能障碍和外周胰岛素抵抗为特征的慢性疾病,患病率在全球范围内逐步上升。长期的糖尿病还会导致一系列并发症,例如大血管并发症(心血管疾病)和微血管并发症(糖尿病肾病、糖尿病视网膜病变和神经病变)。黄芪是众多抗糖尿病中药复方的关键组成之一,对糖尿病及其并发症具有良好的治疗作用。黄芪多糖是黄芪中的重要活性成分,具有改善消化系统、改善糖脂代谢、抗氧化、调节免疫等功能。本文将基于国内外实验研究,综述了黄芪多糖治疗2型糖尿病及其并发症的主要机制及相关信号通路。Type 2 diabetes mellitus with increasing prevalence worldwide is a chronic disease characterized by pancreaticβ-cell dysfunction and peripheral insulin resistance.Long-term diabetes also leads to many complications,such as macrovascular complications(cardiovascular diseases)and microvascular complications(diabetic nephropathy,diabetic retinopathy and neuropathy).Astragalus is a key component of many antidiabetic herbal compounds with favorable therapeutic effect on diabetes and its complications.Astragalus polysaccharides is an important active ingredient in Astragalus,which can improve digestion and glycolipid metabolism,and regulate antioxidation and immunity.In this paper,we reviewed the main mechanism and related signaling pathways of astragalus polysaccharide in the treatment of type 2 diabetes and its complications based on experimental studies home and abroad.

关 键 词：黄芪多糖 2型糖尿病 胰岛素抵抗 信号通路 

分 类 号：R587.1[医药卫生—内分泌] R285[医药卫生—内科学]