线粒体动态平衡在老年患者围术期神经认知障碍中的研究进展  

Research progress on mitochondrial homeostasis in perioperative neurocognitive disorders in elderly patients

作　　者：吕梦溪 徐志鹏 LYU Mengxi;XU Zhipeng(Department of medicine,Ningbo University,Ningbo 315211,China)

机构地区：[1]宁波大学医学部,315211 [2]上海市浦东医院复旦大学医学院附属浦东医院麻醉科

出　　处：《临床麻醉学杂志》2025年第4期432-435,共4页Journal of Clinical Anesthesiology

基　　金：国家自然科学基金(82071179)。

摘　　要：围术期神经认知障碍(PND)是一种常见的神经系统并发症,在老年患者中的发生率较高,与手术应激和神经炎症等多种因素有关。线粒体动态平衡对认知功能密切相关,它通过调控能量代谢、氧化应激等过程影响着神经元的生存和死亡。沉默信息调节因子2相关酶(SIRT)1/过氧化物酶体增殖物激活受体γ共激活因子-1α(PGC-1α)/SIRT3通路可能通过对中枢线粒体动态平衡的调控,在PND的发生和发展中起着关键作用,这一通路的激活可以促进突触可塑性的增强,同时还可以抑制神经元的凋亡,从而改善认知功能。Postoperative cognitive dysfunction(PND)is a common neurological complication,and has high occurrence rate in the elderly population.It is related to many factors such as surgical stress and neuroinflammation.Mitochondrial homeostasis is closely related to cognitive function,and it affects the survival and death of neurons by regulating energy metabolism,oxidative stress and other processes.Sirtuin(SIRT)1/peroxisome-proliferator-activated receptorγcoactivator-1α(PGC-1α)/SIRT3 pathway may play a key role in the occurrence and development of PND through the regulation of central mitochondrial homeostasis.Activation of this pathway can promote the enhancement of synaptic plasticity and inhibit the apoptosis of neurons,thereby improving cognitive function.

关 键 词：围术期神经认知功能障碍 老年 沉默信息调节因子2相关酶 过氧化物酶体增殖物激活受体γ共激活因子-1α 线粒体 

分 类 号：R614[医药卫生—麻醉学]