透明质酸支架联合脂肪干细胞促进下肢慢性创面愈合的研究  

Hyaluronic acid scaffold combined with adipose⁃derived stem cells

作　　者：秦傲霜 杨晨 崔鑫 马戈甲 郭小伟 周煦川 刘宾 QIN Aoshuang;YANG Chen;CUI Xin;MA Gejia;GUO Xiaowei;ZHOU Xuchuan;LIU Bin(Department of Burn and Plastic Surgery,Xi′an Central Hospital Affiliated to Xi′an Jiaotong University,Xi′an 710003,Shaanxi,China)

机构地区：[1]西安交通大学附属西安市中心医院烧伤整形美容外科,陕西西安710003

出　　处：《实用医学杂志》2025年第7期991-996,共6页The Journal of Practical Medicine

基　　金：陕西省重点研发计划一般项目(编号:2020SF-184)。

摘　　要：目的旨在评估透明质酸(hyaluronic acid,HA)支架联合脂肪干细胞(adiposederived stem cells,ADSCs)在下肢慢性创面愈合的临床效果,探索其在促进慢性创面愈合中的应用潜力。方法本研究共纳入50例患者,按随机数字表法将其分为研究组与对照组,两组患者均为25例。研究组将HA与ADSCs按1∶1比例混合,将0.1 mL/cm^(3)HA-ADSCs复合物均匀注射于创面基底及创周皮下组织;对照组仅采用ADSCs注射于创面基底及创周皮下组织。对比两组患者治疗后的感染率、治疗满意度,第7、14、28天的的创面愈合率、疼痛视觉模拟评分(visual analogue score,VAS)和创面量化评分。结果研究组感染率较对照组低(P<0.05);在治疗后第14、28天,研究组创面愈合率高于对照组(P<0.05);在治疗后第7、14、28天,VAS得分和创面量化评分低于对照组(P<0.05);研究组的治疗满意度(92%)高于对照组的(80%)。结论HA支架联合ADSCs可促进下肢慢性创面愈合,降低感染率并减轻创面疼痛,为慢性创面治疗提供了新的思路。Objective This study aimed to evaluate the clinical effect of hyaluronic acid(HA)scaffold combined with adipose⁃derived stem cells(ADSCs)in chronic wound healing of lower limbs and explore its application potential in promoting chronic wound healing.Methods A total of 50 patients were included in this study.They were divided into study and control groups according to the random number table method.There were 25 cases in each of the two groups of patients.HA and ADSCs were mixed in a 1∶1 ratio and evenly injected into the wound base and the subcutaneous tissue around the wound at a rate of 0.1 ml/cm³.In the control group,ADSCs were only injected into the wound base and subcutaneous tissue around the wound.The infection rate,treatment satisfaction,wound healing rate,visual analogue score(VAS),and wound quantitative score were compared between the two groups at 7 days,14 days,and 28 days.Results The infection rate in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Moreover,at 14 days and 28 days after treatment,the wound healing rate in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).On the 7th,14th,and 28th days after treatment,the VAS scores and the wound quantitative scores were lower than those in the control group,and the difference was statistically significant(P<0.05).Furthermore,the treatment satisfaction rate in the research group(92%)was higher than that in the control group(80%).Conclusion HA scaffold combined with ADSCs could promote the healing of chronic wounds in lower limbs,reduce infection rate,and relieve wound pain,which provides a new idea for the treatment of chronic wounds.

关 键 词：透明质酸 脂肪干细胞 创面愈合 感染率 疼痛视觉模拟评分 

分 类 号：R622.9[医药卫生—整形外科]