TRPV1介导腹泻型肠易激综合征内脏高敏感的机制及针刺干预研究进展  

Research progress on the mechanism of TRPV1 in visceral hypersensitivity of IBS-D and acupuncture interventions

作　　者：马源鑫 梅笑 王云峥 王伟[3] MA Yuanxin;MEI Xiao;WANG Yunzheng;WANG Wei(College of Traditional Chinese Medicine,Shandong University of Chinese Medicine,Jinan 250355,China;不详)

机构地区：[1]山东中医药大学中医学院,山东济南250355 [2]山东中医药大学第一临床医学院,山东济南250355 [3]山东中医药大学附属医院消化内二科,山东济南250012

出　　处：《实用医学杂志》2025年第7期1084-1090,共7页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:81904128);国家中医药管理局科技司共建科技项目(编号:GZY-KJS-SD-2023-035);山东省中医药重点学科建设项目(编号:鲁卫中医药科教字〔2022〕4号);山东省中医药科技项目(编号:M-2023167);山东省重点实验室重组建设项目(编号:PKL2024C23)。

摘　　要：瞬时受体电位香草素亚型1(TRPV1)是一种非选择性阳离子通道,广泛分布于胃肠道感觉神经纤维和非神经元细胞中,在介导腹泻型肠易激综合征(IBS-D)内脏高敏感中扮演重要角色。针刺通过活化穴区处TRPV1受体,促进体表物理刺激转化为体内化学信号,协同神经、内分泌、免疫等系统,以多机制、多通路抑制内脏TRPV1表达,临床治疗IBS-D效果显著。本文从TRPV1与脑肠轴失衡、肠道低度炎症、肠道菌群失衡的关系等方面,对TRPV1在IBS-D内脏高敏感中的机制进行综述,梳理针刺靶向TRPV1治疗IBS-D的研究现状,以期为针刺治疗功能性疾病提供科学依据和临床思路。Transient Receptor Potential Vanilloid-1(TRPV1)is a non-selective cation channel that is widely distributed in the sensory nerve fibers and non-neuronal cells of the gastrointestinal tract.It plays a critical role in mediating visceral hypersensitivity in Diarrhea-Predominant Irritable Bowel Syndrome(IBS-D).Acupuncture activates TRPV1 receptors at the acupoint area,promoting the transformation of physical stimuli at the body surface into chemical signals within the body.This process coordinates with the nervous,endocrine,and immune systems to inhibit the expression of TRPV1 in the viscera through multiple mechanisms and pathways,demonstrating significant clinical efficacy in the treatment of IBS-D.This article reviews the mechanisms of TRPV1 in IBS-D visceral hypersensitivity,focusing on its relationship with the gut-brain axis imbalance,low-grade intestinal inflammation,and gut microbiota dysbiosis.It also summarizes the current research on acupuncture targeting TRPV1 in the treatment of IBS-D,aiming to provide scientific evidence and clinical insights for acupuncture therapy in functional diseases.

关 键 词：瞬时受体电位香草素亚型1 腹泻型肠易激综合征 内脏高敏感 机制 针刺 

分 类 号：R259[医药卫生—中西医结合]