慢性阻塞性肺疾病相关性膈肌功能障碍研究进展  

Research progress of diaphragm dysfunction associated with chronic obstructive pulmonary disease

作　　者：黄虎 秦秋玲 张先明(综述) 李礼(审校)[1,2] Huang Hu;Qin Qiuling;Zhang Xianming;Li Li(Guizhou Medical University,Guizhou,Guiyang 550004,China;不详)

机构地区：[1]贵州医科大学,贵阳市550004 [2]贵州医科大学第二附属医院呼吸与危重症医学科,贵州省凯里市556000 [3]贵州医科大学附属医院呼吸与危重症医学科,贵阳市550004

出　　处：《疑难病杂志》2025年第4期494-498,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：贵州省卫生健康委科学技术基金项目(gzwkj2023-296)。

摘　　要：慢性阻塞性肺疾病(COPD)是以持续性气流受限为特征的常见肺部疾病,在COPD引起的多种肺外效应中,膈肌功能障碍尤为突出。膈肌作为主要的呼吸肌,其功能障碍直接影响患者的通气效率,是导致COPD逐渐加重及呼吸衰竭的关键病理机制之一,并与疾病的病死率密切相关。尽管近年来,随着临床医生对此病理状态的深入研究以及诊疗技术的不断进步与创新,COPD相关膈肌功能障碍日益受到关注,但目前尚缺乏统一且规范的治疗方案。因此文章就COPD相关性膈肌功能障碍的研究进展作一综述。Chronic obstructive pulmonary disease(COPD)is a common lung disease characterized by persistent airflow limitation,and diaphragmatic dysfunction is particularly prominent among the multiple extrapulmonary effects caused by COPD.Diaphragm,as the main respiratory muscle,whose dysfunction directly affects the ventilation efficiency of patients,is one of the key pathological mechanisms leading to the progressive exacerbation of COPD and respiratory failure,and is closely related to the mortality of the disease.Although COPD-associated diaphragm dysfunction has received increasing attention in recent years with the in-depth study of this pathology by clinicians and the continuous progress and innovation of diagnostic and therapeutic techniques,there is a lack of uniform and standardized treatment protocols at present.The purpose of this article is to review the pathogenesis of COPD-associated diaphragmatic dysfunction and its therapeutic strategies.

关 键 词：慢性阻塞性肺疾病 膈肌功能障碍 呼吸康复 

分 类 号：R563[医药卫生—呼吸系统] R565[医药卫生—内科学]