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作 者:张文森 王振东 符莹 马国达 陈日玲 ZHANG Wensen;WANG Zhendong;FU Ying;MA Guoda;CHEN Riling(Institute of Pediatric Hematological Oncology,Shunde Women and Children's Hospital of Guangdong Medical University,Foshan,Guangdong,528300;Department of Pediatric Hematological Oncology,Shunde Women and Children's Hospital of Guangdong Medical University,Foshan,Guangdong,528300;Department of Pediatrics,Shunde Women and Children's Hospital of Guangdong Medical University,Foshan,Guangdong,528300)
机构地区:[1]广东医科大学顺德妇女儿童医院儿童血液肿瘤研究所,广东佛山528300 [2]广东医科大学顺德妇女儿童医院儿童血液肿瘤科,广东佛山528300 [3]广东医科大学顺德妇女儿童医院儿科,广东佛山528300
出 处:《实用临床医药杂志》2025年第5期1-8,15,共9页Journal of Clinical Medicine in Practice
基 金:国家自然科学基金项目(81670252);广东省基础与应用基础基金项目(2019A1515011306,2020A1515010240)。
摘 要:目的对全球范围内免疫检查点抑制剂(ICIs)治疗癌症所致心血管免疫相关不良反应(irAEs)领域的文献进行文献计量学分析和可视化分析,探讨其研究现状、热点及未来趋势。方法选用Web of Science Core Collection(WOSCC)为检索平台,检索相关文献并进行筛选,采用CiteSpace软件对国家、机构、作者和关键词等进行可视化分析。结果检索得到1350篇文献,发文量呈逐年上升趋势。在国家、机构、作者的发文量分析中,美国均占据主要地位,欧洲国家及机构合作较为密切。关键词分析和被引文献分析展示了该领域的热点演变:由初始的机制研究到单克隆药物使用,再到其安全性问题。目前,ICIs单克隆抗体联合治疗恶性肿瘤及心血管irAEs,特别是引起致命性的心肌炎,已逐渐成为热点。结论ICIs的单克隆抗体药物治疗以及ICIs引起心血管irAEs等逐渐成为研究热点,特别是药物的联合治疗及致命性心肌炎方面的研究,或可成为未来研究的方向。Objective To conduct a bibliometric and visual analysis of global literature on cardiovascular immune-related adverse events(irAEs)induced by immune checkpoint inhibitors(ICIs)in cancer treatment,and to explore the research status,hotspots,and future trends in this field.Methods The Web of Science Core Collection(WOSCC)database was utilized to retrieve and screen relevant literature.CiteSpace software was employed for visual analysis of countries,institutions,authors,and keywords.Results A total of 1,350 articles were retrieved,with an annual increase in publication volume.The United States dominated in terms of national,institutional,and author contributions,while European countries and institutions demonstrated close collaborative networks.Keyword analysis and cited reference mapping revealed an evolution of research hotspots:from initial mechanistic investigations to monoclonal antibody applications,and subsequently to safety concerns.Current lresearch focuses on ICI monoconal antibody combination therapy for malignancies and cardiovascular irAEs,particularly fatal myocarditis,which has emerged as a prominent topic.Conclusion ICIs monoclonal antibody therapies and their associated cardiovascular irAEs,especially combination therapies and life-threatening myocarditis,represent key research frontiers.Investigations into drug combination strategies and fatal myocarditis may guide future research directions.
关 键 词:免疫检查点抑制剂 心血管免疫相关不良反应 CiteSpace软件 可视化分析 心肌炎 恶性肿瘤 单克隆抗体 文献计量学
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