稽留流产的影响因素分析  

Analysis of influencing factors of missed abortion

作　　者：魏梦珂 迪娜 刘爽 赵旭珍 魏乾坤 张晶 WEI Mengke;DI Na;LIU Shuang;ZHAO Xuzhen;WEI Qiankun;ZHANG Jing(School of Public Health,Xinjiang Medical University,Xinjiang Uygur Autonomous Region,Urumqi830000,China;the First Department of Gynecology,Urumqi Maternal and Child Health Care Hospital,Xinjiang Uygur Autonomous Region,Urumqi830000,China;Medical College,Shihezi University,Xinjiang Uygur Autonomous Region,Shihezi832000,China)

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830000 [2]乌鲁木齐市妇幼保健院妇一科,新疆乌鲁木齐830000 [3]石河子大学医学院,新疆石河子832000

出　　处：《中国医药导报》2025年第8期121-125,共5页China Medical Herald

基　　金：新疆维吾尔自治区乌鲁木齐市妇幼保健院科技计划项目(202302)。

摘　　要：目的 分析稽留流产的影响因素。方法 选择2020年1月至2023年7月于乌鲁木齐市妇幼保健院就诊的137例稽留流产患者为病例组,另选择同期就诊的153名正常妊娠女性作为对照组。收集两组一般资料,分析影响稽留流产的因素,受试者工作特征曲线评估预测价值。结果 两组血β-人绒毛膜促性腺激素(β-h CG)、孕酮、同型半胱氨酸、25-羟基维生素D、游离三碘甲状腺原氨酸、游离甲状腺素、抗心磷脂抗体Ig G、α角及阴道微生态比较,差异有统计学意义(P<0.05)。25-羟基维生素D缺乏、高游离甲状腺素水平、细菌性阴道病及外阴阴道假丝酵母菌病是稽留流产的危险因素(OR=40.213、1.103、10.243、8.367,P<0.05);高血β-h CG、孕酮水平是稽留流产的保护因素(OR=0.803、0.966,P<0.05)。联合预测稽留流产的曲线下面积为0.935。结论 血β-h CG、孕酮、25-羟基维生素D、游离甲状腺素、细菌性阴道病及外阴阴道假丝酵母菌病与稽留流产密切相关,联合检测对稽留流产的早期发现具有重要意义。Objective To analyze the influencing factors of missed abortion.Methods A total of 137 cases of missed abortion patients admitted to Urumqi Maternal and Child Health Care Hospital from January 2020 to July 2023 were selected as case group,another 153 normal pregnant women in the same period were selected as control group.The general data of two groups were selected,the influencing factors were analysis,and the predictive value was evaluated by receiver operating characteristic curve.Results There were significant differences in bloodβ-human chorionic gonadotropin(hCG),progesterone,homocysteine,25-hydroxyvitamin D,free triiodothyronine,free thyroxine,anticardiolipin antibody IgG,αangle,and vaginal microbiota between two groups(P<0.05).25-hydroxyvitamin D deficiency,high free thyroxine,bacterial vaginosis,and vulvovaginal candidiasis were risk factors for missed abortion(OR=40.213,1.103,10.243,8.367,P<0.05);while high bloodβ-hCG and progesterone were protective factors for missed abortion(OR=0.803,0.966,P<0.05).The area under the curve for the combined prediction of missed abortion was 0.935.Conclusion Bloodβ-hCG,progesterone,25-hydroxyvitamin D,free thyroxine,bacterial vaginosis,and vulvovaginal candidiasis are closely related to missed abortion,and combined detection is of great significance for the early detection of missed abortion.

关 键 词：稽留流产 胚胎停育 影响因素 

分 类 号：R714.21[医药卫生—妇产科学]