度骨化醇合成研究进展  

Research Progress on the Synthesis of Doxercalcifero

作　　者：吴鑫慧 岳誉洁 庄小慧 孙彬[2] 金灿[1,2] WU Xinhui;YUE Yujie;ZHUANG Xiaohui;SUN Bin;JIN Can(College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China;Collaborative Innovation Center Yangtze River Delta Region Green Pharmaceuticals,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China)

机构地区：[1]浙江工业大学药学院,浙江杭州310014 [2]浙江工业大学长三角绿色制药协同创新中心,浙江杭州310014

出　　处：《浙江化工》2025年第3期22-28,共7页Zhejiang Chemical Industry

基　　金：国家自然科学基金项目(22478356,22108250)。

摘　　要：度骨化醇是一种维生素D_(2)类似物,具有参与钙磷代谢、骨骼健康、免疫功能调节及某些细胞活动的调控作用,展现出良好的发展前景。本文从不同的起始原料出发,综述了度骨化醇的合成工艺,旨在通过分析现有合成路线的优势与不足,为优化度骨化醇的工业化生产提供参考。Doxercalciferol,a vitamin D_(2) analog,plays a vital role in the regulation of calcium and phosphorus metabolism,bone health,immune function and various cellular activities,demonstrating significant developmental potential.This paper reviews the synthesis routes of doxercalciferol from different starting materials,aiming to provide reference for optimizing the industrial production of doxercalciferol by analyzing the strengths and limitations of existing synthetic processes.

关 键 词：度骨化醇 化学合成法 麦角固醇 麦角三烯甾酮 维生素D_2 

分 类 号：TQ463[化学工程—制药化工]