Distinct tropisms of HCMV and SARS-CoV-2 in lung tissue of a patient with advanced HIV disease  

作　　者：Jingjing Xu Bo Yang Ye Zheng Yuexiang Yang Min-Hua Luo Yun Ling Xiaohong Fan Han Cheng 

机构地区：[1]Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,China [2]State Key Laboratory of Virology,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,China [3]State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,National Center for Magnetic Resonance in Wuhan,Wuhan Institute of Physics and Mathematics,Innovation Academy for Precision Measurement Science and Technology,Chinese Academy of Sciences,Wuhan 430071,China

出　　处：《Virologica Sinica》2025年第1期141-143,共3页中国病毒学(英文版)

基　　金：National Key Research and Development Project of China(2023YFC2306600);Key Program of the National Natural Science Foundation of China(82430070);Shanghai Pujiang Program(No.23PJ1410800);National Natural Science Foundation of China(82072260,32370168);Eastern Talent Plan Leading Project,Shanghai Hospital Development Center Foundation(SHDC12022121);Shanghai 2020“Science and Technology Innovation Action Plan”Medical Innovation Research Special(20Z11900900);Three-year Action Plan(2023-2025);Key Discipline Program on Public Health System Construction of Shanghai(GWVI-11.1-15);Construction of the Major Infectious Disease Medical Treatment System(GWVI-2.2).

摘　　要：Dear Editor,The COVID-19 pandemic,caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has resulted in millions of deaths worldwide.It poses significant challenges in the management of immunocompromised patients,particularly people with HIV(PWH).Whether PWH are more vulnerable to COVID with more adverse outcomes has been extensively studied,but the findings are inconsistent.Many cohort studies and meta-analyses support that PWH have a higher risk of SARSCoV-2 infection and more severe COVID-19 outcomes(Bertagnolio et al.,2022;Ssentongo et al.,2021).

关 键 词：Immunocompromised patients severe acute respiratory syndrome coronavirus Lung tissue TROPISMS HCMV cohort studies SARS CoV HIV 

分 类 号：R512.91[医药卫生—内科学]