阿奇霉素联合辛伐他汀治疗慢性阻塞性肺疾病合并肺动脉高压的临床效果分析  

Clinical Efficacy Analysis of Azithromycin Combined with Simvastatin in the Treatment of Chronic Obstructive Pulmonary Disease with Pulmonary Hypertension

作　　者：李旭 王婷婷 黄瑞 王海旭[1] Li Xu;Wang Tingting;Huang Rui;Wang Haixu(Department of Respiratory and Critical Care Medicine,the Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]新疆医科大学第五附属医院呼吸与危重症医学科,新疆维吾尔自治区乌鲁木齐830011

出　　处：《中外医药研究》2025年第8期21-23,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨阿奇霉素联合辛伐他汀治疗慢性阻塞性肺疾病(简称慢阻肺)合并肺动脉高压的效果。方法:选择2023年5月—2024年3月新疆医科大学第五附属医院收治的102例慢阻肺合并肺动脉高压患者进行研究,以抽签的方式随机分为单药组(实施辛伐他汀治疗)和双药组(实施阿奇霉素与辛伐他汀联合治疗),每组51例。比较两组运动耐力、血气指标、肺功能和生活质量评分。结果:治疗后,两组6 min步行距离延长,双药组长于单药组(P<0.001);治疗后,两组动脉血氧分压升高,动脉血二氧化碳分压下降,双药组优于单药组(P<0.05);治疗后,两组用力肺活量、第1秒用力呼吸容积升高,双药组高于单药组(P<0.05);治疗后,两组活力、精神健康评分升高,双药组高于单药组(P<0.05)。结论:阿奇霉素联合辛伐他汀治疗慢阻肺合并肺动脉高压的效果较好,可有效增强患者运动耐力,改善血气指标、肺功能指标,提高生活质量。Objective:To investigate the efficacy of azithromycin combined with simvastatin in the treatment of chronic obstructive pulmonary disease complicated with pulmonary hypertension.Methods:A total of 102 patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension admitted to the Fifth Affiliated Hospital of Xinjiang MedicalUniversityfrom May 2023 to March 2024 were randomly divided into a monotherapy group(n=51,receiving simvastatin)and a combination group(n=51,receiving azithromycin plus simvastatin)by lottery method.Exercise capacity,blood gas parameters,pulmonary function,and quality of life scores were compared between groups.Results:After treatment,both groups showed increased 6-minute walk distance,the combination group was longer than the monotherapy group(P<0.001).After treatment,arterial oxygen partial pressure in creased while carbon dioxide partial pressure decreased in both groups,with the combination group was better than the monotherapy group(P<0.05).After treatment,forced vital capacity and forced expiratory volume in 1 second improved in both groups,the combination group was higher than the monotherapy group(P<0.05).After treatment,vitality and mental health scores improved in both groups,the combination group was higher than the monotherapy group(P<0.05).Conclusion:The combination of azithromycin and simvastatin demonstrates superior clinical benefits for patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension,significantly enhancing exercise tolerance,improving blood gas exchange and pulmonary function,while elevating quality of life.

关 键 词：慢性阻塞性肺疾病 肺动脉高压 阿奇霉素 辛伐他汀 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统] R544.1[医药卫生—内科学]