Potential Protective or Pathogenic Roles of Parabacteroides distasonis in Diseases:A Narrative Review  

作　　者：Chaozhong Luo Hainv Gao 

机构地区：[1]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,National Medical Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China [2]Department of Infectious Diseases,Shulan Hangzhou Hospital,Hangzhou,China

出　　处：《Infectious Microbes & Diseases》2025年第1期27-34,共8页感染微生物与疾病(英文)

基　　金：supported by the National Key Research and Development Program(2021YFA1301104 and 2022YFC2304505);National Natural Science Foundation of China(81790634).

摘　　要：Parabacteroides distasonis is a gram-negative,non–spore-forming,rod-shaped,anaerobic bacterium,and an important gut colonizer first iso-lated from human feces in 1933.Over more than 90 years of research,P.distasonis has been found to be associated with liver diseases such as liver fibrosis and nonalcoholic fatty liver disease,gastrointestinal diseases such as colitis and colorectal tumors,and metabolic diseases such as obesity and diabetes,potentially playing a protective or pathogenic role in the occurrence and progression of these diseases.Herein,we elaborate on the biological characteristics,antibiotic resistance and potential roles of P.distasonis in these diseases,aiming to provide re-searchers with comprehensive information about P.distasonis and promote in-depth investigations into its safety and protective effects.

关 键 词：Parabacteroides distasonis antibiotic resistance liver fibrosis inflammatory bowel disease MECHANISM 

分 类 号：R37[医药卫生—病原生物学]