Multidrug-Resistant Gram-Negative Bacteria in Surgical Site Infections:Antimicrobial Resistance and Preventive Measures  

作　　者：Sunil Kumar Anil Kumar Sharma Mukesh Yadav Nirmala Sehrawat Durgesh Kumar Jaiswal 

机构地区：[1]Department of Microbiology,Graphic Era(Deemed to be University),Dehradun,Uttarakhand,India [2]Department of Biotechnology,Amity University,Mohali,Punjab,India [3]Department of Bio-Sciences&Technology,Maharishi Markandeshwar(Deemed to be University),Mullana(Ambala),India [4]Department of Biotechnology,Graphic Era(Deemed to be University),Dehradun,Uttarakhand,India.

出　　处：《Infectious Microbes & Diseases》2025年第1期35-42,共8页感染微生物与疾病(英文)

摘　　要：Multidrug-resistant(MDR)gram-negative bacteria(GNB)are responsible for high mortality and morbidity in health care settings world-wide.They have been declared as priority pathogens by the WHO for their continuously escalating antimicrobial resistance.Neverthe-less,data associated with MDR GNB in health care–associated infections are insufficient.Surgical site infections(SSIs)are among the most commonly occurring health care–associated infections.Such infections are particularly common when bacteria from a patient’s normal microflora are transferred to the surgical sites during surgical procedures.SSIs affect approximately 0.5%–3%of patients under-going surgery,resulting in prolonged hospital stays compared with patients without SSIs.SSIs result in severe problems and lead to a heavy economic burden.Most SSIs can be avoided if suitable preventive measures are employed.Novel findings support the dedicated usage of oral preoperative surgical antimicrobial prophylaxis for specific surgeries based on sites/organs.Immediate interventions are sought to control the transmission of MDR GNB typically found in hospital settings.The present narrative review aims to describe MDR GNB in SSIs in different sites.Antimicrobial resistance epidemiology and preventive measures for SSIs are also discussed.Differ-ent intrinsic and extrinsic factors and control measures are elaborated for curbing SSIs.

关 键 词：gram-negative bacteria health care-associated infections surgical antimicrobial prophylaxis surgical site infections multidrug resistance 

分 类 号：R446.5[医药卫生—诊断学] R63[医药卫生—临床医学]