内镜介入联合吡非尼酮治疗瘢痕性中心气道狭窄4例  

Endoscopic intervention combined with pirfenidone for the treatment of cicatricial central airway stenosis:a report of 4 cases

作　　者：李晓[1] 马芸[1] 王培[1] 张杰[1] 潘金兵[1] Li Xiao;Ma Yun;Wang Pei;Zhang Jie;Pan Jinbing(Department of Respiratory Medicine,Henan Provincial People's Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院呼吸科,郑州450003

出　　处：《中华结核和呼吸杂志》2025年第4期378-381,共4页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：回顾性分析4例瘢痕性中心气道狭窄的临床资料,比较应用吡非尼酮前后的患者介入治疗时间、介入治疗前气道直径和呼吸困难指数评分。结果显示2例患者的介入治疗时间间隔明显延长,4例患者的介入治疗前气道直径明显增大,4例患者的气促症状得到改善,患者的介入治疗次数明显减少。本研究提示吡非尼酮对瘢痕性中心气道狭窄有治疗作用。A retrospective analysis of the clinical data of four patients with cicatricial central airway stenosis was performed.The study compared the intervals between interventional treatments,the airway diameter before interventional treatment,and the dyspnea index scores of the patients before and after the use of pirfenidone.The results showed that the intervals between interventional treatments were significantly prolonged in two patients,the airway diameters before interventional treatment were significantly increased and the symptoms of dyspnea were improved in all four patients.In addition,the number of interventional treatments was reduced.This study suggested that pirfenidone might have therapeutic potential in cicatricial central airway stenosis.

关 键 词：瘢痕性中心气道狭窄 吡非尼酮 

分 类 号：R562[医药卫生—呼吸系统]