舒心调更方联合治疗围绝经期冠心病伴焦虑/抑郁患者的效果观察  

Observation on the Effect of Shuxin Tiaogeng Decoction in the Treatment of Perimenopausal Coronary Heart Disease Complicated with Anxiety/Depression

作　　者：苏星宇 徐丹丹 王玉霞 武星旭 吕晓杰 赵立俊 苏海燕 张京红 SU Xingyu;XU Dandan;WANG Yuxia;WU Xingxu;LVY Xiaojie;ZHAO Lijun;SU Haiyan;ZHANG Jinghong(Department of Traditional Chinese Medicine,the Fourth Hospital of Zhangjiakou City,Zhangjiakou,Hebei 075000,China;Department of Medical Devices,the Fourth Hospital of Zhangjiakou City,Zhangjiakou,Hebei 075000,China;Department of Medical Devices,the Seventh People's Hospital of Hengshui City,Hengshui,Hebei 075000,China;Department of Internal Medicine,the Seventh People's Hospital of Hengshui City,Hengshui,Hebei 075000,China;Department of Gynecology and Obstetrics,Jingxing County Hospital,Jingxing,Hebei 053800,China;Department of Laboratory,the Fourth People's Hospital of Hengshui City,Hengshui,Hebei 050300,China)

机构地区：[1]张家口市第四医院中医内科,河北张家口075000 [2]张家口市第四医院药械科,河北张家口075000 [3]衡水市第七人民医院药械科,河北衡水075000 [4]衡水市第七人民医院内科,河北衡水075000 [5]井陉县医院妇产科,河北井陉053800 [6]衡水市第四人民医院检验科,河北衡水050300

出　　处：《临床误诊误治》2025年第8期85-90,共6页Clinical Misdiagnosis & Mistherapy

基　　金：河北省中医药管理局科技计划项目(2025501)。

摘　　要：目的探究舒心调更方联合治疗围绝经期冠心病伴焦虑/抑郁患者的临床效果。方法选取2023年6月至2023年12月收治的围绝经期冠心病焦虑/抑郁患者50例,采用随机数字表法分为西药组、中药组各25例。中药组予舒心调更方联合常规西药治疗,西药组予常规西药治疗,2组均治疗4周。观察比较2组临床疗效,治疗前后2组焦虑抑郁状态、血清性激素及神经递质变化,以及治疗期间2组不良反应情况。结果中药组治疗总有效率为92.00%(23/25)显著高于西药组的76.00%(19/25),差异有统计学意义(P<0.05)。治疗后,2组抑郁自评量表及焦虑自评量表评分明显降低,且中药组降低幅度大于西药组(P<0.05,P<0.01)。治疗后,2组血清雌二醇(E 2)水平显著升高,血清促卵泡刺激素(FSH)及黄体生成素(LH)水平显著降低,且中药组血清E 2升高幅度大于西药组,血清FSH及LH降低幅度大于西药组(P<0.05,P<0.01)。治疗后,2组血清神经肽Y(NPY)及5-羟色胺(5-HT)水平均显著升高,血清髓过氧化物酶(MPO)水平显著降低,且中药组血清NPY及5-HT升高幅度大于西药组,血清MPO降低幅度大于西药组(P<0.05,P<0.01)。中药组不良反应发生率低于西药组(P<0.05)。结论舒心调更方联合治疗围绝经期冠心病伴焦虑/抑郁患者效果肯定,并可改善患者临床症状,调节性激素及神经递质水平,在治疗冠心病的同时还可降低其焦虑和抑郁程度。Objective To explore the clinical effect of Shuxin Tiaogeng decoction in the treatment of perimenopausal coronary heart disease(CHD)complicated with anxiety/depression.Methods Fifty perimenopausal patients with CHD and anxiety/depression from June 2023 to December 2023 were selected and divided into western medicine group and Traditional Chinese Medicine(TCM)group based on random number table method,with 25 patients in each group.The patients in the TCM group were treated with Shuxin Tiaogeng decoction combined with conventional western medicine,and the patients in western medicine group were treated with conventional western medicine.Both groups were treated for 4 weeks.The clinical efficacy,the changes of anxiety and depression,serum hormone indexes and neurotransmitter before and after treatment,and the adverse reactions during treatment were observed and compared between the two groups.Results The total effective rate of the TCM group was 92.00%(23/25),which was significantly higher than 76.00%(19/25)of the western medicine group,and the difference was significant(P<0.05).After treatment,the scores of self-rating depression scale(SDS)and self-rating anxiety scale(SAS)in the two groups were significantly decreased,and the decreases in the TCM group were greater than those in the western medicine group(P<0.05,P<0.01).After treatment,the levels of serum estradiol(E 2)in the two groups were significantly increased,and the levels of serum follicle stimulating hormone(FSH)and luteinizing hormone(LH)were significantly decreased.The increase of serum E 2 level in the TCM group was greater than that in the western medicine group,and the decrease of serum FSH and LH was greater than that in the western medicine group(P<0.05,P<0.01).After treatment,the levels of serum neuropeptide Y(NPY)and 5-hydroxytryptamine(5-HT)in the two groups were significantly increased,while the level of serum myeloperoxidase(MPO)was significantly decreased,and the increase of serum NPY and 5-HT levels in the TCM group was greater than that in

关 键 词：围绝经期 冠心病 焦虑 抑郁 舒心调更方 雌二醇 5-羟色胺 药物毒性 

分 类 号：R473.5[医药卫生—护理学]